A low resolution model for the interaction of G proteins with G protein-coupled receptors

A low resolution model for the interaction of G proteins with G protein-coupled receptors

Autor Oliveira, Laerte Autor UNIFESP Google Scholar
Paiva, Antonio Cechelli de Mattos Autor UNIFESP Google Scholar
Vriend, Gerrit Google Scholar
Instituição European Mol Biol Lab
Universidade Federal de São Paulo (UNIFESP)
Resumo A model is presented for the interaction between G proteins and G protein-coupled receptors, the model is based on the fact that this interaction shows Little specificity and thus conserved parts of the G proteins have to interact with conserved parts of the receptors. These parts are a conserved negative residue in the G protein, a fully conserved arginine in the receptor and a series of residues that are not conserved but always hydrophobic like the hydrophobic side of the C-terminal helix of the G protein and the hydrophobic side of a helix in the C-terminal domain of the receptor. Other, mainly cytosolic, factors determine the specificity and regulation of this interaction. the relation between binding and activation will be shown. ii large body of experimental evidence supports this model. Despite the fact that the model does not provide atomic resolution, it can be used, to explain some experimental data that would otherwise seem inexplicable, and it suggests experiments for its falsification or verification.
Palavra-chave GPCR
G protein interaction
model
Idioma Inglês
Data de publicação 1999-12-01
Publicado em Protein Engineering. Oxford: Oxford Univ Press, v. 12, n. 12, p. 1087-1095, 1999.
ISSN 0269-2139 (Sherpa/Romeo, fator de impacto)
Publicador Oxford Univ Press
Extensão 1087-1095
Fonte http://dx.doi.org/10.1093/protein/12.12.1087
Direito de acesso Acesso aberto Open Access
Tipo Resenha
Web of Science WOS:000084683000011
Endereço permanente http://repositorio.unifesp.br/handle/11600/26180

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