Naltrexone potentiates the anxiolytic effects of chlordiazepoxide in rats exposed to novel environments

Naltrexone potentiates the anxiolytic effects of chlordiazepoxide in rats exposed to novel environments

Autor Frussa-Filho, R. Google Scholar
Barbosa-Junior, H. Google Scholar
Silva, R. H. Google Scholar
Da Cunha, C. Google Scholar
Mello, C. F. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Univ Fed Parana
Universidade Federal de Sergipe (UFS)
Resumo Rationale: Both novelty and naloxone have been reported to modify the anxiolytic-like effect of benzodiazepines in the elevated plus maze. in addition, it has been largely demonstrated that novelty alters endogenous opioid activity. Objectives: the present study was designed to examine a possible interaction between novelty and naltrexone effects on the behavior of chlordiazepoxide-treated rats in two animal models of anxiety. Methods: Thirty minutes after acute intraperitoneal treatment with saline or naltrexone and saline or chlordiazepoxide, male Wistar rats were exposed for the first time to the elevated plus maze apparatus or the social interaction arena for the quantification of the percentage of time spent in the open arms or the time of active social interaction, respectively. the effects of naltrexone and/or chlordiazepoxide on the plus maze and the social interaction tests were also evaluated after previous exposure to the respective apparatus. Results: Naltrexone dose dependently increased the percentage of time spent in the open arms of the elevated plus maze in chlordiazepoxide-treated (5 mg/kg i.p.) rats exposed for the first time to the apparatus. Similarly, naltrexone (5 mg/kg i.p.) increased the time spent in active social interaction by chlordiazepoxide-treated rats exposed to an unfamiliar arena. in both experiments, naltrexone had no effect when administered alone. When both the plus maze and the social interaction tests were conducted after previous exposure to the respective apparatus, naltrexone did not modify the behavior of chlordiazepoxide- or saline-treated rats. Conclusions: These data suggest that the anxiolytic-like effects of chlordiazepoxide can be modified by opioid mechanisms in navel environments.
Palavra-chave anxiety
elevated plus maze
chlordiazepoxide
naltrexone
novelty
Idioma Inglês
Data de publicação 1999-11-01
Publicado em Psychopharmacology. New York: Springer, v. 147, n. 2, p. 168-173, 1999.
ISSN 0033-3158 (Sherpa/Romeo, fator de impacto)
Publicador Springer
Extensão 168-173
Fonte http://dx.doi.org/10.1007/s002130051157
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000084016600007
Endereço permanente http://repositorio.unifesp.br/handle/11600/26165

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