Conditioning to injection procedures and repeated testing increase SCH 23390-induced catalepsy in mice

Conditioning to injection procedures and repeated testing increase SCH 23390-induced catalepsy in mice

Autor Chinen, Cibele Cristina Autor UNIFESP Google Scholar
Frussa Filho, Roberto Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The cataleptic behavior induced by the dopamine D-1 antagonist SCH 23390 (SCH) has proven to be a useful assay for investigating the sensitivity of D-1-like dopamine receptor-mediated effects during chronic drug administration. A fundamental flaw in most of these studies may be the involvement of the repeated measures effect, a behavioral phenomenon well demonstrated for neuroleptic-induced catalepsy but not yet investigated for dopamine D-2 antagonists. in this study, mice exposed for various sessions to the bar test presented a strong sensitization to the cataleptic behavior induced by repeated SCH treatment. Conversely, single tested animals exhibited a trend toward decreased catalepsy after repeated SCH treatment, which was in line with the development of a D-1-like dopamine receptor supersensitivity suggested by an increase in SKF 38393-induced grooming behavior. Surprisingly, a challenge intraperitoneal saline injection increased the cataleptic behavior of single tested mice after long-term SCH treatment. This injection-conditioned catalepsy was also observed after repented treatment with the dopamine D-2 antagonists, haloperidol and metoclopramide. While these findings seem to explain some important contradictory data in the literature, they provide a new and simple animal model of the placebo effect. [Neuropsychopharmacology 21:670-678,1999] (C) 1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.
Palavra-chave catalepsy conditioning
SCH 23390
dopamine D-1 receptor
placebo effect
Idioma Inglês
Data de publicação 1999-11-01
Publicado em Neuropsychopharmacology. New York: Elsevier B.V., v. 21, n. 5, p. 670-678, 1999.
ISSN 0893-133X (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 670-678
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000082807900008
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