MYCN gene amplification - Identification of cell populations containing double minutes and homogeneously staining regions in neuroblastoma tumors

MYCN gene amplification - Identification of cell populations containing double minutes and homogeneously staining regions in neuroblastoma tumors

Autor Yoshimoto, Maisa Autor UNIFESP Google Scholar
Toledo, Silvia Regina Caminada de Autor UNIFESP Google Scholar
Caran, Eliana Maria Monteiro Autor UNIFESP Google Scholar
Seixas, Maria Teresa de Autor UNIFESP Google Scholar
Lee, Maria Lucia de Martino Autor UNIFESP Google Scholar
Abib, Simone de Campos Vieira Autor UNIFESP Google Scholar
Vianna, Sonia Maria Rossi Google Scholar
Schettini, Sergio Tomaz Autor UNIFESP Google Scholar
Andrade, Joyce Anderson Duffles Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Hosp Servidor Publ Estadual
Resumo Neuroblastoma is the second most common solid tumor occurring in children. Amplification of the MYCN oncogene is associated with poor prognosis. To identify neuroblastoma tumors with MYCN amplification, we studied the number of copies of MYCN in interphase cells by fluorescence in situ hybridization in 20 neuroblastoma patients. MYCN amplification appeared in 7 tumor specimens. Interphase and metaphase studies showed a tumor cell population with both forms of amplification, double minutes and homogeneously staining regions, in two patients. These patients showed a smaller tumor cell subpopulation with the presence of more than one homogeneously staining region, suggesting that gene amplification was undergoing karyotype evolution.
Idioma Inglês
Data de publicação 1999-11-01
Publicado em American Journal of Pathology. Baltimore: Amer Soc Investigative Pathology, Inc, v. 155, n. 5, p. 1439-1443, 1999.
ISSN 0002-9440 (Sherpa/Romeo, fator de impacto)
Publicador Amer Soc Investigative Pathology, Inc
Extensão 1439-1443
Fonte http://dx.doi.org/10.1016/S0002-9440(10)65457-0
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000083587600007
Endereço permanente http://repositorio.unifesp.br/handle/11600/26163

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