Glomerular detection of schistosomal antigen by immunoelectron microscopy in human mansonian schistosomiasis

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dc.contributor.author DeBrito, T.
dc.contributor.author Nussenzveig, I
dc.contributor.author Carneiro, CRW
dc.contributor.author Nakhle, M. C.
dc.contributor.author Carvalho, S.
dc.contributor.author Silva, AMG
dc.contributor.author Sandoval, M.
dc.contributor.author Saldanha, L. B.
dc.date.accessioned 2016-01-24T12:30:54Z
dc.date.available 2016-01-24T12:30:54Z
dc.date.issued 1999-10-01
dc.identifier http://dx.doi.org/10.1177/106689699900700404
dc.identifier.citation International Journal of Surgical Pathology. Glen Head: Westminster Publ Inc, v. 7, n. 4, p. 217-225, 1999.
dc.identifier.issn 1066-8969
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/26159
dc.description.abstract Schistosomal antigens (S. mansoni) were detected in glomeruli of nine patients with nephropathy and nephrotic syndrome by immunoelectron microscopy. the criteria for patients' selection were presence of intestinal schistosomiasis and absence of any surgical or other medical diseases, particularly lupus erythematosus, syphilis, and hepatitis B and C, which could explain the renal disease. When examined by light microscopy, kidney biopsies showed type I membranoproliferative glomerulonephritis in four patients, focal segmental glomerulosclerosis in two, and mesangioproliferative glomerulonephritis, membranous glomerulonephritis, and minimal change disease in one each of the remaining three patients. Immunofluorescence showed mainly immunoglobulin G (IgG), IgM, and different complement components (C3, C1q) deposits, particularly in the mesangial area, in eight patients. All patients had gold-labeled schistosomal antigen deposits in their glomeruli, chiefly in mesangial cells and matrix, along the glomerular membrane, and occasionally in the cytoplasm of epithelial cells. Although membranous glomerulonephritis has been rarely described in association with schistosomiasis and minimal change disease may be occasionally caused by an infectious disease like syphilis, the absence of definite experimental models and epidemiologic data suggests that coincidental pathologies without causal relationship with schistosomiasis cannot be ruled our to explain these findings. en
dc.format.extent 217-225
dc.language.iso eng
dc.publisher Westminster Publ Inc
dc.relation.ispartof International Journal of Surgical Pathology
dc.rights Acesso restrito
dc.subject schistosomiasis mansoni en
dc.subject antigen en
dc.subject immunoelectron microscopy en
dc.subject human schistosomal nephropathy en
dc.title Glomerular detection of schistosomal antigen by immunoelectron microscopy in human mansonian schistosomiasis en
dc.type Artigo
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ São Paulo, Sch Med, Hosp Clin, Inst Trop Med,Dept Pathol, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Sch Med, Hosp Clin, Inst Trop Med,Dept Nephrol, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Sch Med, Hosp Clin, Inst Trop Med,Dept Infect Dis, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, Brazil
dc.identifier.doi 10.1177/106689699900700404
dc.description.source Web of Science
dc.identifier.wos WOS:000083483000004



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