Glomerular detection of schistosomal antigen by immunoelectron microscopy in human mansonian schistosomiasis

Glomerular detection of schistosomal antigen by immunoelectron microscopy in human mansonian schistosomiasis

Autor DeBrito, T. Google Scholar
Nussenzveig, I Google Scholar
Carneiro, CRW Google Scholar
Nakhle, M. C. Google Scholar
Carvalho, S. Google Scholar
Silva, AMG Google Scholar
Sandoval, M. Google Scholar
Saldanha, L. B. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo Schistosomal antigens (S. mansoni) were detected in glomeruli of nine patients with nephropathy and nephrotic syndrome by immunoelectron microscopy. the criteria for patients' selection were presence of intestinal schistosomiasis and absence of any surgical or other medical diseases, particularly lupus erythematosus, syphilis, and hepatitis B and C, which could explain the renal disease. When examined by light microscopy, kidney biopsies showed type I membranoproliferative glomerulonephritis in four patients, focal segmental glomerulosclerosis in two, and mesangioproliferative glomerulonephritis, membranous glomerulonephritis, and minimal change disease in one each of the remaining three patients. Immunofluorescence showed mainly immunoglobulin G (IgG), IgM, and different complement components (C3, C1q) deposits, particularly in the mesangial area, in eight patients. All patients had gold-labeled schistosomal antigen deposits in their glomeruli, chiefly in mesangial cells and matrix, along the glomerular membrane, and occasionally in the cytoplasm of epithelial cells. Although membranous glomerulonephritis has been rarely described in association with schistosomiasis and minimal change disease may be occasionally caused by an infectious disease like syphilis, the absence of definite experimental models and epidemiologic data suggests that coincidental pathologies without causal relationship with schistosomiasis cannot be ruled our to explain these findings.
Palavra-chave schistosomiasis mansoni
antigen
immunoelectron microscopy
human schistosomal nephropathy
Idioma Inglês
Data de publicação 1999-10-01
Publicado em International Journal of Surgical Pathology. Glen Head: Westminster Publ Inc, v. 7, n. 4, p. 217-225, 1999.
ISSN 1066-8969 (Sherpa/Romeo, fator de impacto)
Publicador Westminster Publ Inc
Extensão 217-225
Fonte http://dx.doi.org/10.1177/106689699900700404
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000083483000004
Endereço permanente http://repositorio.unifesp.br/handle/11600/26159

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta