Effect of physical exercise on seizure occurrence in a model of temporal lobe epilepsy in rats

Effect of physical exercise on seizure occurrence in a model of temporal lobe epilepsy in rats

Autor Arida, R. M. Google Scholar
Scorza, F. A. Google Scholar
Santos, N. F. dos Google Scholar
Peres, C. A. Google Scholar
Cavalheiro, E. A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Although the favorable effect of physical fitness on general health is unquestionable, physical exercise and fitness programs in patients with epilepsy are still a matter of controversy. Little objective evidence regarding the effect of exercise on seizure frequency and severity has been reported. One sought to clarify the relationship between exercise and epilepsy in an animal model of temporal lobe epilepsy (the pilocarpine model of epilepsy). To evaluate the effect of an aerobic physical program on seizure frequency, 29 epileptic animals were continuously monitored during 24 h for 135 days after the first spontaneous recurrent seizure (SRS) and divided into three groups. the first group (N = 14) was submitted to an aerobic exercise program (training group). the second group (N = 7) was maintained in the treadmill for the same time as the training group without being submitted to physical exercise (sham group). the third group (N = 8) served as control. the behavioral observation was divided in three periods of 45 days. the first period was used to determine the number of seizures before physical training program. the second period was utilized to determine the number of seizures during the physical training program. the third period was used to analyze the frequency of seizures after the physical training program. the mean frequency of seizures in the control and sham groups increased significantly from period 1 to period 2 and from period 1 to period 3. However, in the training group, the frequency of seizures did not change significantly between the three periods of 45 days of observation. When the same periods of the three groups were analyzed together, a significant reduction in seizure frequency was observed comparing the training group with the control and sham groups during the period of physical training. the data presented in this study suggest that physical exercise is not a seizure-inducing factor in this experimental model of epilepsy. (C) 1999 Elsevier Science B.V. All rights reserved.
Palavra-chave exercise
epilepsy
pilocarpine
temporal lobe epilepsy
Idioma Inglês
Data de publicação 1999-10-01
Publicado em Epilepsy Research. Amsterdam: Elsevier B.V., v. 37, n. 1, p. 45-52, 1999.
ISSN 0920-1211 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 45-52
Fonte http://dx.doi.org/10.1016/S0920-1211(99)00032-7
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000082848800006
Endereço permanente http://repositorio.unifesp.br/handle/11600/26153

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