Bovine brain phosphatidylserine attenuates scopolamine-induced amnesia

Bovine brain phosphatidylserine attenuates scopolamine-induced amnesia

Autor Claro, F. T. Google Scholar
Silva, R. H. Google Scholar
Frussa, R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The effects of bovine cerebral cortex phosphatidylserine (BCPS) on the memory impairment induced by scopolamine in mice tested in the plus-maze discriminative avoidance task Were investigated. Swiss male mice received daily i.p. 50 mg/kg BCPS or 0.2 M Tris pH 7.4 (TRIS) for 5 days. Twenty-four hours after the last injection, the animals received 1 mg/kg scopolamine (BCPS-SCO and TRIS-SCO) or saline (BCPS-SAL and TRIS-SAL) i.p. After 20 min, the animals were submitted to discriminative avoidance conditioning. in the test, performed 24 h later, BCPS-SCO, BCPS-SAL, and TRIS-SAL (but not TRIS-SCO) mice spent significantly less time in the aversive enclosed arm of the discriminative avoidance apparatus when compared to the time spent in the nonaversive enclosed arm. the results suggest that BCPS attenuates scopolamine-induced amnesia in a discriminative avoidance task. (C) 1999 Elsevier Science Inc.
Palavra-chave memory
learning
phosphatidylserine
scopolamine
Idioma Inglês
Data de publicação 1999-10-01
Publicado em Physiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 67, n. 4, p. 551-554, 1999.
ISSN 0031-9384 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 551-554
Fonte http://dx.doi.org/10.1016/S0031-9384(99)00099-2
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000083291400009
Endereço permanente http://repositorio.unifesp.br/handle/11600/26150

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