Bovine brain phosphatidylserine attenuates scopolamine-induced amnesia

Bovine brain phosphatidylserine attenuates scopolamine-induced amnesia

Author Claro, F. T. Google Scholar
Silva, R. H. Google Scholar
Frussa, R. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The effects of bovine cerebral cortex phosphatidylserine (BCPS) on the memory impairment induced by scopolamine in mice tested in the plus-maze discriminative avoidance task Were investigated. Swiss male mice received daily i.p. 50 mg/kg BCPS or 0.2 M Tris pH 7.4 (TRIS) for 5 days. Twenty-four hours after the last injection, the animals received 1 mg/kg scopolamine (BCPS-SCO and TRIS-SCO) or saline (BCPS-SAL and TRIS-SAL) i.p. After 20 min, the animals were submitted to discriminative avoidance conditioning. in the test, performed 24 h later, BCPS-SCO, BCPS-SAL, and TRIS-SAL (but not TRIS-SCO) mice spent significantly less time in the aversive enclosed arm of the discriminative avoidance apparatus when compared to the time spent in the nonaversive enclosed arm. the results suggest that BCPS attenuates scopolamine-induced amnesia in a discriminative avoidance task. (C) 1999 Elsevier Science Inc.
Keywords memory
learning
phosphatidylserine
scopolamine
Language English
Date 1999-10-01
Published in Physiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 67, n. 4, p. 551-554, 1999.
ISSN 0031-9384 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 551-554
Origin http://dx.doi.org/10.1016/S0031-9384(99)00099-2
Access rights Closed access
Type Article
Web of Science ID WOS:000083291400009
URI http://repositorio.unifesp.br/handle/11600/26150

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