Decreased point prevalence of Haemophilus influenzae type b (Hib) oropharyngeal colonization by mass immunization of Brazilian children less than 5 years old with Hib polyribosylribitol phosphate polysaccharide-tetanus toroid conjugate vaccine in combination with diphtheria-tetanus toxoids-pertussis vaccine

Decreased point prevalence of Haemophilus influenzae type b (Hib) oropharyngeal colonization by mass immunization of Brazilian children less than 5 years old with Hib polyribosylribitol phosphate polysaccharide-tetanus toroid conjugate vaccine in combination with diphtheria-tetanus toxoids-pertussis vaccine

Autor Forleo-Neto, E. Google Scholar
Oliveira, C. F. de Autor UNIFESP Google Scholar
Maluf, EMCP Google Scholar
Bataglin, C. Google Scholar
Araujo, JMR Google Scholar
Kunz, L. F. Google Scholar
Pustai, A. K. Google Scholar
Vieria, VSD Google Scholar
Zanella, R. C. Google Scholar
Brandileone, M. C. Google Scholar
Mimica, LMJ Google Scholar
Mimica, I. M. Google Scholar
Instituição Pasteur Merieux Connaught Brasil
Universidade Federal de São Paulo (UNIFESP)
Secretaria Estado Saude São Paulo
Santa Casa Misericordia São Paulo
Secretaria Municipal Saude Curitiba
Secretaria Municipal Saude Porto Alegre
Resumo A protective herd effect has been described after susceptible populations of children are vaccinated with conjugate Haemophilus influenzae type b (Hib), Hib carriage was studied in children aged 6-24 months attending day care centers in two cities in southern Brazil (Curitiba and Porto Alegre), in Curitiba, routine immunization with Hib polyribosylribitol phosphate polysaccharide-tetanus toroid conjugate vaccine (PRP-T) in combination with diphtheria-tetanus toxoids-pertussis vaccine (PRP-T/DTP) has been offered since September 1996; DTP vaccine alone is routinely given in Porto Alegre, Children in Porto Alegre (n = 643) were 8 times less likely to have received adequate Hib vaccination and 4 times more likely to be Hib carriers than children in Curitiba (n = 647; i.e., point prevalence of oropharyngeal colonization, 4.8% vs. 1.2%). Point prevalence of carriage with non-type b or other nontypeable Hi was similar in children of both cities, There was a vaccination effect on carriage rates in children who received a primary 3-dose series, independent of the booster dose, suggesting that a booster may be unnecessary to induce population protection.
Idioma Inglês
Data de publicação 1999-10-01
Publicado em Journal of Infectious Diseases. Chicago: Univ Chicago Press, v. 180, n. 4, p. 1153-1158, 1999.
ISSN 0022-1899 (Sherpa/Romeo, fator de impacto)
Publicador Univ Chicago Press
Extensão 1153-1158
Fonte http://dx.doi.org/10.1086/315018
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000083019500028
Endereço permanente http://repositorio.unifesp.br/handle/11600/26144

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