Sialic acids in fungi: A minireview

Sialic acids in fungi: A minireview

Autor Alviano, C. S. Google Scholar
Travassos, L. R. Google Scholar
Schauer, R. Google Scholar
Instituição Univ Kiel
Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Federal de São Paulo (UNIFESP)
Resumo The increasing number of reports on the presence of sialic acids in fungi (N-acetyl, N-glycolyl-and 5,9-N,O-diacetyl neuraminic acids) based on direct and indirect evidence warrants the present review. Formerly suggested as sialidase-sensitive sources of anionic groups at the cell surface of fungal species grown in chemically defined media (e.g., Fonsecaea pedrosoi), sialic acids have also been found in Sporothrix schenckii, Paracoccidioides brasiliensis, Cryptococcus neoformans and recently, in Candida albicans. Methods used involved adequate hydrolysis and extraction procedures, HTPLC, gas-chromatography, colorimetry, mass spectroscopy, sialidase-sensitive lectin and influenza virus binding. Apart from protecting fungal cells against phagocytosis (S. schenckii, C. neoformans) and playing a cellular structural role (F. pedrosoi), other biological functions of sialic acids are still being investigated.
Palavra-chave fungi
sialic acids
anionic groups
N-acetylneuraminic acid
O-acetylated sialic acids
fungal pathogenesis
Idioma Inglês
Data de publicação 1999-09-01
Publicado em Glycoconjugate Journal. Dordrecht: Kluwer Academic Publ, v. 16, n. 9, p. 545-554, 1999.
ISSN 0282-0080 (Sherpa/Romeo, fator de impacto)
Publicador Kluwer Academic Publ
Extensão 545-554
Fonte http://dx.doi.org/10.1023/A:1007078106280
Direito de acesso Acesso restrito
Tipo Resenha
Web of Science WOS:000085542100008
Endereço permanente http://repositorio.unifesp.br/handle/11600/26138

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