Haloperidol increases spreading and nitric oxide production in macrophages from tumor-bearing mice: a possible mechanism for its antitumoral effect

Haloperidol increases spreading and nitric oxide production in macrophages from tumor-bearing mice: a possible mechanism for its antitumoral effect

Autor Kleeb, SR Google Scholar
Rizzo, M. D. Google Scholar
Dagli, MLZ Google Scholar
Frussa, R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo Subcutaneous treatment with haloperidol (2.0 mg/kg) was found to increase both the percent of macrophage spreading and nitric oxide (NO) release in peritoneal macrophage from animals inoculated intraperitoneally with 5.0 x 10(6) Ehrlich ascites cells. This haloperidol-induced macrophage activation seems to be involved in its antitumoral effect since cotreatment with the iNOS inhibitor aminoguanidine was able to reverse the inhibitory effect of haloperidol on the development of the Ehrlich solid carcinoma. (C) 1999 International Society for Immunopharmacology, Published by Elsevier B.V. All rights reserved.
Palavra-chave haloperidol
Ehrlich adenocarcinoma
macrophage
nitric oxide
Idioma Inglês
Data de publicação 1999-09-01
Publicado em International Journal of Immunopharmacology. Oxford: Pergamon-Elsevier B.V., v. 21, n. 9, p. 575-580, 1999.
ISSN 0192-0561 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 575-580
Fonte http://dx.doi.org/10.1016/S0192-0561(99)00036-3
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000082203300003
Endereço permanente http://repositorio.unifesp.br/handle/11600/26136

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