Treatment of periodic leg movements with a dopaminergic agonist in subjects with total spinal cord lesions

Treatment of periodic leg movements with a dopaminergic agonist in subjects with total spinal cord lesions

Autor Mello, Marco Tulio de Autor UNIFESP Google Scholar
Poyares, Dalva Lucia Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Uberlândia (UFU)
Resumo Objective: To investigate the effect of L-dopa on the PLM/h index of spinal cord injured subjects.Setting: São Paulo, Brazil.Methods: Thirteen male volunteers with spinal cord section between T7-T12, and mean age of 31.6 +/- 8.3 years participated in the study. L-dopa or placebo were administered for 30 days, 1 h before the volunteers went to sleep, in a double blind, crossover design. Polysomnographic recordings were performed on ten occasions: Phase I: Basal night, following an adaptation night at the sleep laboratory; phase 2: after 1, 7, 21 and 30 days of L-dopa administration; phase 3: first night of L-dopa or placebo withdrawal; phase IV: 1, 7, 21 and 30 days after placebo ingestion.Results: the index of PLM/h on the first night of L-dopa or placebo withdrawal (phase III) was lower than on both the basal night and the first night of L-dopa treatment, At the time of polysomnographic analysis, volunteers were divided into two groups: index of PLM/h below five and those whose index was above five. Comparison between L-dopa and placebo treatments revealed that only those volunteers with an index above five revealed a reduction in PLM in L-dopa.Conclusion: These results indicate that despite the spinal cord lesions, L-dopa treatment is capable of minimizing PLM during sleep.
Palavra-chave sleep
spinal cord lesion(s)
L-dopa
periodic leg movements (PLM)
paraplegic
restless legs syndrome (RLS)
Idioma Inglês
Data de publicação 1999-09-01
Publicado em Spinal Cord. Basingstoke: Stockton Press, v. 37, n. 9, p. 634-637, 1999.
ISSN 1362-4393 (Sherpa/Romeo, fator de impacto)
Publicador Stockton Press
Extensão 634-637
Fonte http://dx.doi.org/10.1038/sj.sc.3100909
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000082627800004
Endereço permanente http://repositorio.unifesp.br/handle/11600/26131

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