Antigenic properties of the merozoite surface protein 1 gene of Plasmodium vivax

Antigenic properties of the merozoite surface protein 1 gene of Plasmodium vivax

Autor Oliveira, C. I. de Google Scholar
Wunderlich, G. Google Scholar
Levitus, G. Google Scholar
Soares, I. S. Google Scholar
Rodrigues, M. M. Google Scholar
Tsuji, M. Google Scholar
del Portillo, H. A. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo Plasmodium vivax is responsible for an approximate 35 million yearly human cases of malaria. Unfortunately, due to the low mortality rate associated with it and the difficulties of continuously in vitro culturing of this parasite, vaccine development against this human malaria has been largely neglected. in here, the antigenic properties of the merozoite surface protein 1 gene of P. vivax (PvMSP-1), were studied. Thus, seven recombinant bacterial plasmids coding different regions of the PvMSP-1 protein were constructed and used to immunize BALB/c mice, the results demonstrated that a plasmid encoding the entire N-terminus comprising 682 amino acids and a plasmid encoding the C-terminus including the two juxtaposed epidermal growth factor (EGF)-like domains fused to the Hepatitis B surface antigen, were antigenic. Moreover, the elicited immune responses were similar to those reported for these same PvMSP-1 regions in natural human infections. (C) 1999 Published by Elsevier B.V. All rights reserved.
Assunto Plasmodium vivax
merozoite surface protein 1
DNA vaccines
Idioma Inglês
Data 1999-08-06
Publicado em Vaccine. Oxford: Elsevier B.V., v. 17, n. 23-24, p. 2959-2968, 1999.
ISSN 0264-410X (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 2959-2968
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000081957300004

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