Ascorbic acid and alpha-tocopherol attenuate methylmalonic acid-induced convulsions

Ascorbic acid and alpha-tocopherol attenuate methylmalonic acid-induced convulsions

Autor Fighera, M. R. Google Scholar
Queiroz, C. M. Google Scholar
Stracke, M. P. Google Scholar
Brauer, MCN Google Scholar
Gonzalez-Rodriguez, L. L. Google Scholar
Frussa, R. Google Scholar
Wajner, M. Google Scholar
Mello, C. F. de Google Scholar
Instituição Universidade Federal de Sergipe (UFS)
Universidade Federal de São Paulo (UNIFESP)
Univ Fed Rio Grande Sul
Resumo THE effects of chronic administration of alpha-tocopherol or melatonin, or acute ascorbic acid administration on the convulsant action of methylmalonic acid (MMA) were investigated in adult male rats. Animals were chronically injected with alpha-tocopherol (40 mg kg(-1), i.p.), melatonin (5 mg kg(-1), i.p.) or vehicle for 7 days. Buffered MMA (6 mu mol/2 mu l) or NaCl (9 mu mol/2 mu l) was injected intrastriatally and the animals were observed for the appearance of clonic or tonic-clonic convulsions and rotational behavior. Ascorbic acid (100 mg kg(-1), s.c.) was administered 30 min before MMA injection. alpha-Tocopherol and ascorbic acid pretreatment decreased the duration of the convulsive episodes and the rotational behavior elicited by MMA, This study provides evidence that free radical generation may participate in the convulsant effects of methylmalonic acid. NeuroReport 10:2039-2043 (C) 1999 Lippincott Williams & Wilkins.
Palavra-chave antioxidants
ascorbic acid
convulsion
excitotoxicity
glutamate
melatonin
methylmalonic acid
succinate dehydrogenase
alpha-tocopherol
Idioma Inglês
Data de publicação 1999-07-13
Publicado em Neuroreport. Philadelphia: Lippincott Williams & Wilkins, v. 10, n. 10, p. 2039-2043, 1999.
ISSN 0959-4965 (Sherpa/Romeo, fator de impacto)
Publicador Lippincott Williams & Wilkins
Extensão 2039-2043
Fonte http://dx.doi.org/10.1097/00001756-199907130-00009
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000081354200009
Endereço permanente http://repositorio.unifesp.br/handle/11600/26112

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