Evaluation of serum levels of IgG subclasses and anti-ribosyl-ribitolphosphate IgG and IgG2 in children with Haemophilus influenzae b meningitis

Evaluation of serum levels of IgG subclasses and anti-ribosyl-ribitolphosphate IgG and IgG2 in children with Haemophilus influenzae b meningitis

Author Ishigami-Miyake, T. T. Autor UNIFESP Google Scholar
Nagao, A. T. Google Scholar
Arslanian, C. Autor UNIFESP Google Scholar
Harima, H. A. [UNIFES] Google Scholar
Costa-Carvalho, B. T. Autor UNIFESP Google Scholar
Carneira-Sampaio, MMS Google Scholar
Farhat, C. K. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract In 40 children with Haemophilus influenzae b (Hib) meningitis, we determined serum levels (mg/dl) of IgG subclasses using the radial immunodiffusion method; 67.8 per cent of these children were less than 24 months old. in 14 children of the sample we measured serum IgG and IgG2 anti-ribosyl-ribitolphosphate (anti-PRP) (by enzyme-linked immunosorbent assay, ELISA) in the acute and convalescent phases of the disease, Lower IgG2 levels than those of the control group were obtained in all age ranges: 3-12 months, 1-2 years (p < 0.01), and 2-5 years (p < 0.002), IgG4 was also present in lower levels in patients of ail age ranges (p < 0.05, p < 0.001, and p < 0.01 respectively), Serum levels of IgG anti-PRP and IgG2 anti-PRP measured were very low in the acute phase of the disease in all age ranges and there was no notable increase in levels during the convalescent phase of the disease. This result indicates that children less than 24 months old do not produce sufficient levels of IgG and IgG2 anti-PRP even after Hib meningitis.
Language English
Date 1999-06-01
Published in Journal of Tropical Pediatrics. Oxford: Oxford Univ Press, v. 45, n. 3, p. 130-134, 1999.
ISSN 0142-6338 (Sherpa/Romeo, impact factor)
Publisher Oxford Univ Press
Extent 130-134
Origin http://dx.doi.org/10.1093/tropej/45.3.130
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000081136900002
URI http://repositorio.unifesp.br/handle/11600/26083

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