Organization of telomeric and sub-telomeric regions of chromosomes from the protozoan parasite Trypanosoma cruzi

Organization of telomeric and sub-telomeric regions of chromosomes from the protozoan parasite Trypanosoma cruzi

Autor Chiurillo, M. A. Google Scholar
Cano, I Google Scholar
Da Silveira, J. F. Google Scholar
Ramirez, J. L. Google Scholar
Instituição Cent Univ Venezuela
Inst Estudios Avanzados
Universidade Federal de São Paulo (UNIFESP)
Resumo We present here a characterization of the telomeric and subtelomeric regions of Trypanosoma cruzi chromosomes, using three types of recombinants: cosmids from a genomic library, clones obtained by a vector-adaptor protocol, and a recombinant fragment cloned by a Bal31 trimming protocol. the last nine nucleotides of the T. cruzi overhang are 5'-GGGTTAGGG-3', and there are from 9 to 50 copies of the hexameric repeat 5'-TTAGGG-3', followed by a 189-bp junction sequence common to all recombinants. the subtelomeric region is made of sequences associated with the gp85/sialidase gene family, and/or sequences derived from SIRE, a retrotransposon-like sequence, and also the retrotransposon L1Tc. We discuss the possible implications of this genome organization. (C) 1999 Elsevier Science B.V. All rights reserved.
Assunto Trypanosoma cruzi
telomere organization
surface glycoproteins
Idioma Inglês
Data 1999-05-25
Publicado em Molecular and Biochemical Parasitology. Amsterdam: Elsevier B.V., v. 100, n. 2, p. 173-183, 1999.
ISSN 0166-6851 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 173-183
Fonte http://dx.doi.org/10.1016/S0166-6851(99)00047-X
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000080756700003
URI http://repositorio.unifesp.br/handle/11600/26081

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