Organization of telomeric and sub-telomeric regions of chromosomes from the protozoan parasite Trypanosoma cruzi

Organization of telomeric and sub-telomeric regions of chromosomes from the protozoan parasite Trypanosoma cruzi

Autor Chiurillo, M. A. Google Scholar
Cano, I Google Scholar
Da Silveira, J. F. Google Scholar
Ramirez, J. L. Google Scholar
Instituição Cent Univ Venezuela
Inst Estudios Avanzados
Universidade Federal de São Paulo (UNIFESP)
Resumo We present here a characterization of the telomeric and subtelomeric regions of Trypanosoma cruzi chromosomes, using three types of recombinants: cosmids from a genomic library, clones obtained by a vector-adaptor protocol, and a recombinant fragment cloned by a Bal31 trimming protocol. the last nine nucleotides of the T. cruzi overhang are 5'-GGGTTAGGG-3', and there are from 9 to 50 copies of the hexameric repeat 5'-TTAGGG-3', followed by a 189-bp junction sequence common to all recombinants. the subtelomeric region is made of sequences associated with the gp85/sialidase gene family, and/or sequences derived from SIRE, a retrotransposon-like sequence, and also the retrotransposon L1Tc. We discuss the possible implications of this genome organization. (C) 1999 Elsevier Science B.V. All rights reserved.
Palavra-chave Trypanosoma cruzi
telomere organization
surface glycoproteins
Idioma Inglês
Data de publicação 1999-05-25
Publicado em Molecular and Biochemical Parasitology. Amsterdam: Elsevier B.V., v. 100, n. 2, p. 173-183, 1999.
ISSN 0166-6851 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 173-183
Fonte http://dx.doi.org/10.1016/S0166-6851(99)00047-X
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000080756700003
Endereço permanente http://repositorio.unifesp.br/handle/11600/26081

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