Pathological extension of prostate cancer as defined by gleason score on biopsy

Pathological extension of prostate cancer as defined by gleason score on biopsy

Autor Dall'Oglio, Marcos Francisco Autor UNIFESP Google Scholar
Crippa, Alexandre Autor UNIFESP Google Scholar
Paranhos, Mario Autor UNIFESP Google Scholar
Nesrallah, Luciano J. Autor UNIFESP Google Scholar
Leite, Kátia Ramos Moreira Autor UNIFESP Google Scholar
Srougi, Miguel Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo INTRODUCTION: Based on the importance of the Gleason score on the behavior of prostate adenocarcinoma, this study attempts to predict the extension of prostate adenocarcinoma pre-operatively, as defined by the Gleason score on biopsy, in individuals who will undergo radical prostatectomy. MATERIALS AND METHODS: We selected 899 individuals who underwent retropubic radical prostatectomy from 1988 to 2004. Clinical and pathological data obtained in the preoperative period were retrospectively analyzed through digital rectal examinations of the prostate, initial serum PSA levels and pathological data provided by biopsy. The Gleason score on biopsy was assessed and divided into 3 groups: 2 to 6, 7, and 8 to 10, and correlated with the possibility of the disease being confined to the prostate. RESULTS: From the 899 selected patients, 654 (74%) showed Gleason scores of 2 to 6, 165 (18%) had a score of 7 and 80 (9%) had scores of 8 to 10 on biopsy. The likelihood of confined diseases, extraprostatic extensions, invasion of seminal vesicles and lymph nodal involvement were respectively: 74%, 18%, 8% and 0.8% for a Gleason score of 2 to 6, 47%, 30%, 19% and 4% for a Gleason score of 7, and 49%, 29%, 18% and 4% for a Gleason score of 8 to 10. CONCLUSION: In patients who will undergo radical prostatectomy due to prostate adenocarcinoma, a Gleason score of 7 on biopsy shows the same behavior as a Gleason score of 8 to 10 in relation to extension of disease.
Palavra-chave prostatic neoplasms
neoplasm staging
biopsy
needle
pathology
Idioma Inglês
Data de publicação 2005-08-01
Publicado em International braz j urol. Sociedade Brasileira de Urologia, v. 31, n. 4, p. 326-330, 2005.
ISSN 1677-5538 (Sherpa/Romeo)
Publicador Sociedade Brasileira de Urologia
Extensão 326-330
Fonte http://dx.doi.org/10.1590/S1677-55382005000400005
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S1677-55382005000400005 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/2608

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