Prevalence of epileptic seizures along the wakefulness-sleep cycle in adult rats submitted to status epilepticus in early life

Prevalence of epileptic seizures along the wakefulness-sleep cycle in adult rats submitted to status epilepticus in early life

Autor Ferreira, BLC Google Scholar
Valle, A. C. Google Scholar
Cavalheiro, E. A. Google Scholar
Timo-Iaria, C. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo In 70 adult Wistar rats submitted to pilocarpine-induced status epilepticus in early life the electro-oscillograms were recorded from neocortical areas 10, 3 and 17, from CA1 and CA3 hippocampal fields and, in 10 rats, also from the ventrolateral nuclei and amygdala. Head, eye, rostrum + vibrissae, ear and forelimb movements were recorded as well. Fifty rats were subjected to 4-hour daily recording sessions and 20 to continuous 24-hour recordings. in all the rats spike-wave discharges (SWD) were found in every site from which the electro-oscillograms were recorded, and clonic seizures were also displayed by all the animals, Most seizures (83.75%, mean = 6.59 fits/h) were concentrated in nearly 9 h and 16.25% (mean = 0.77 fits/h) in the remaining 15 h. Eye movements occurred during 49.2% of the total duration of motor events, the head moved in 42.8% and the rostrum + vibrissae in 8.1 % of the time, departing from normal rats. Therefore, pilocarpine-induced status epilepticus produces striking changes in the wakefulness-sleep cycle characteristics. Copyright (C) 1999 S. Karger AG, Basel.
Palavra-chave epilepsy
sleep
wakefulness
pilocarpine
desynchronized sleep
Idioma Inglês
Data de publicação 1999-05-01
Publicado em Developmental Neuroscience. Basel: Karger, v. 21, n. 3-5, p. 339-344, 1999.
ISSN 0378-5866 (Sherpa/Romeo, fator de impacto)
Publicador Karger
Extensão 339-344
Fonte http://dx.doi.org/10.1159/000017383
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000084057600020
Endereço permanente http://repositorio.unifesp.br/handle/11600/26078

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