Ethanol intake during lactation impairs milk production in rats and affects growth and metabolism of suckling pups

Ethanol intake during lactation impairs milk production in rats and affects growth and metabolism of suckling pups

Autor Do Carmo, MGT Google Scholar
Do Nascimento, CMO Google Scholar
Martin, A. Google Scholar
Herrera, E. Google Scholar
Instituição Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Federal de São Paulo (UNIFESP)
Hosp Ramon y Cajal
Univ San Pablo
Resumo From parturition, lactating Wistar rats were given 20% alcohol in drinking water and fed a solid diet ad lib (group AL). Pair-fed (PF) and control (C) rats were fed solid diet and given water ad lib (C). All animals were sacrificed on the 12th day of lactation. Ethanol treatment decreased food intake and milk production in lactating rats to a greater level than in PF rats, and a greater reduction in body weight of the AL pups was noted. Brain weight, protein concentration, and DNA content were also lower in pups of AL dams than of PF dams, whereas liver glycogen concentration was higher in the former. Pups from AL dams had higher circulating levels of beta-OH-butyrate, triglyceride, and free fatty acids than those from either C or PF dams. Plasma glucose concentration was lower in both PF and AL than in C pups, whereas the AL group had lower plasma protein concentration than any of the other groups. We conclude that maternal alcohol intake during lactation greatly impairs milk production, and although the known increase of lipid content in milk in rats studied under similar conditions allows an enhanced lipidic components in the pups, this adaptation does not allow normal growth and brain development. (C) 1999 Elsevier Science Inc. All rights reserved.
Palavra-chave alcohol
lactation
malnutrition
milk production
pup's growth
liver
brain
rat
Idioma Inglês
Data de publicação 1999-05-01
Publicado em Alcohol. New York: Elsevier B.V., v. 18, n. 1, p. 71-76, 1999.
ISSN 0741-8329 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 71-76
Fonte http://dx.doi.org/10.1016/S0741-8329(98)00070-6
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000080763000012
Endereço permanente http://repositorio.unifesp.br/handle/11600/26075

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