Phyllanthus niruri inhibits calcium oxalate endocytosis by renal tubular cells: Its role in urolithiasis

Phyllanthus niruri inhibits calcium oxalate endocytosis by renal tubular cells: Its role in urolithiasis

Autor Campos, A. H. Google Scholar
Schor, N. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo We investigated the in vitro effect of an aqueous extract of Phyllanthus niruri L, on a model of CaOx crystal endocytosis by Madin-Darby canine kidney cells. the extract exhibited a potent and effective non-concentration-dependent inhibitory effect on the CaOx crystal internalization This response was present even at very high (pathologic) CaOx concentrations and no P, niruri L.-induced toxic effect could be detected. Biochemical analysis of culture media containing P. niruri L. did not provide any clues for the elucidation of the cellular pathways affected by this natural product. Although further studies are necessary for a better understanding of the role of P, niruri L, in urolithiasis, our findings show that this natural product could be an attractive alternative for the treatment of urinary stones.
Palavra-chave Phyllanthus niruri
calcium oxalate
Madin-Darby canine kidney cells
endocytosis
renal stone
Idioma Inglês
Data de publicação 1999-04-01
Publicado em Nephron. Basel: Karger, v. 81, n. 4, p. 393-397, 1999.
ISSN 0028-2766 (Sherpa/Romeo, fator de impacto)
Publicador Karger
Extensão 393-397
Fonte http://dx.doi.org/10.1159/000045322
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000079607200005
Endereço permanente http://repositorio.unifesp.br/handle/11600/26062

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