Distribution and composition of glycosaminoglycans in the left human coronary arterial branches under myocardial bridge

Distribution and composition of glycosaminoglycans in the left human coronary arterial branches under myocardial bridge

Autor Shinjo, S. K. Google Scholar
Prates, NEVB Google Scholar
Oba, S. M. Google Scholar
Sampaio, L. O. Google Scholar
Nader, H. B. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo The distribution and composition of glycosaminoglycans (GAGs) are reported in the anterior interventricular branch under the intermyocardial bridge (MB) and the ventricular branch without bridge, both from the left human coronary artery. Chondroitin sulfate (CS), dermatan sulfate (DS) and heparan sulfate (HS) were purified and quantified by a combination of electrophoretic migration and enzymatic degradation. the absolute amounts of GAGs in the intermyocardial bridge segment (MB) increased by 47%, when compared to the pre (PreMB) and post (PostMB) segments and the ventricular arterial branch (VB). Furthermore, the relative distribution of GAGs in the intermyocardial bridge segment differs when compared to the pre and post segments as well as in the ventricular arterial branch, due to a change in the proportion of DS and CS of 41.9 and 32.4%, compared to 36.4 and 39.7%, respectively. These findings give support to the possible involvement of GAGs in the intermyocardial bridge segment, avoiding local thrombus deposition, reducing atherosclerotic development and moreover giving protection against vessel deformation caused by the systolic pressure. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
Palavra-chave glycosaminoglycans
heparan sulfate
chondroitin sulfate
human coronary artery
myocardial bridge
Idioma Inglês
Data de publicação 1999-04-01
Publicado em Atherosclerosis. Clare: Elsevier Sci Ireland Ltd, v. 143, n. 2, p. 363-368, 1999.
ISSN 0021-9150 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 363-368
Fonte http://dx.doi.org/10.1016/S0021-9150(98)00323-2
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000079595800015
Endereço permanente http://repositorio.unifesp.br/handle/11600/26055

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