First synthesis of a fully active spin-labeled peptide hormone

First synthesis of a fully active spin-labeled peptide hormone

Autor Barbosa, Simone Reis [UNIFESP Google Scholar
Cilli, Eduardo Maffud Autor UNIFESP Google Scholar
Lamy-Freund, M. T. Google Scholar
Castrucci, AML Google Scholar
Nakaie, Clovis Ryuichi Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo For the first time in the electron spin resonance (ESR) and peptide synthesis fields, a fully active spin-labeled peptide hormone was reported. the ESR spectra of this alpha-melanocyte stimulating hormone (alpha-MSH) analogue (acetyl-Toac(0)-alpha-MSH) where Toac is the paramagnetic amino acid probe 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid, suggested a pH-independent conformation and a more restricted movement comparatively to the free Toac, Owing to its equivalent biological potency in a skin pigmentation assay as compared to the native alpha-MSH and its unique characteristic (paramagnetic, naturally fluorescent and fully active), this analogue is of great potential for investigation of relevant physiological roles reported for a-MSH, (C) 1999 Federation of European Biochemical Societies.
Palavra-chave spin-labeled peptide
alpha-melanocyte stimulating hormone
electron spin resonance
skin pigmentation
Idioma Inglês
Data de publicação 1999-03-05
Publicado em Febs Letters. Amsterdam: Elsevier B.V., v. 446, n. 1, p. 45-48, 1999.
ISSN 0014-5793 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 45-48
Fonte http://dx.doi.org/10.1016/S0014-5793(99)00172-6
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000079123100011
Endereço permanente http://repositorio.unifesp.br/handle/11600/26045

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