Pregnancy outcome after exposure to misoprostol in Brazil: A prospective, controlled study

Pregnancy outcome after exposure to misoprostol in Brazil: A prospective, controlled study

Autor Schuler, L. Google Scholar
Pastuszak, A. Google Scholar
Sanseverino, MTV Google Scholar
Orioli, I. M. Google Scholar
Brunoni, D. Google Scholar
Ashton-Prolla, P. Google Scholar
Costa, F. S. da Google Scholar
Giugliani, R. Google Scholar
Couto, A. M. Google Scholar
Brandao, S. B. Google Scholar
Koren, G. Google Scholar
Instituição Hosp Sick Children
Univ Fed Rio Grande Sul
Clin Hosp
Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Federal de São Paulo (UNIFESP)
Univ Toronto
Resumo Background: Misoprostol, a synthetic prostaglandin E1 analog is labeled for the treatment of gastric and duodenal ulcers, in Brazil, where abortion is not a legal procedure, there is a widespread popular misuse of this drug in abortion attempts. This misuse and the fact that, in many cases the desired pregnancy termination does not occur, raise concerns about fetal safety. Case reports of congenital anomalies after maternal use of misoprostol have been published. the objective of this work was to compare pregnancy outcome following misoprostol exposure with a matched control group, This is the first prospective controlled study on fetal safety after misoprostol use. Methods: A prospective, observational cohort study with 86 exposed and 86 pair-matched, non-exposed controls. Results: There was no significant difference in the rates of major or minor birth between exposed compared to non-exposed infants (2/67 vs 2/81, major defects; 7/67 vs. 3/81, minor anomalies) There were significantly more miscarriages in the exposed group (17.1% vs, 5.8%; relative risk, 2.97; 95% confidence interval, 1.12 to 7.88), There was no statistical difference in gestational age at delivery, birth weight, sex ratio, rate of prematurity, low birth weight, or rates of cesarean section between groups. Conclusions: Our study, despite its limited statistical power, does not suggest a potent teratogenic action of misoprostol exposure during pregnancy. (C) 1999 Elsevier Science Inc.
Palavra-chave misoprostol
pregnancy complications
abnormalities
drug induced
Idioma Inglês
Data de publicação 1999-03-01
Publicado em Reproductive Toxicology. Oxford: Pergamon-Elsevier B.V., v. 13, n. 2, p. 147-151, 1999.
ISSN 0890-6238 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 147-151
Fonte http://dx.doi.org/10.1016/S0890-6238(98)00072-0
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000079524300008
Endereço permanente http://repositorio.unifesp.br/handle/11600/26043

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