Human serum beta(2)-microglobulin levels: correlation with total serum IgG and placental IgG transfer in HIV-infected and non-HIV infected individuals

Human serum beta(2)-microglobulin levels: correlation with total serum IgG and placental IgG transfer in HIV-infected and non-HIV infected individuals

Autor Moraes-Pinto, M. I. de Google Scholar
Farhat, C. K. Google Scholar
Fraser, W. D. Google Scholar
Hart, C. A. Google Scholar
Johnson, P. M. Google Scholar
Instituição Univ Liverpool
Universidade Federal de São Paulo (UNIFESP)
Resumo The acquisition of maternal immunoglobulin G (IgG) is fundamental to the immune defence of the neonate. the receptor responsible for Ige transfer across the human placenta has also been implicated in the maintenance of IgG levels in the circulation. beta(2)-microglobulin is part of the Fc receptor (FcR) that has recently been purified from the human placenta. in HIV infection, increasing serum levels of total IgG and beta(2)-microglobulin are observed as the disease progresses. Herein: we have investigated the correlation between beta(2)-microglobulin and total serum IgG levels in HIV-seropositive mothers and their term neonates (HIV group, n = 37), as well as in HIV-seronegative mothers and their term neonates (control group, n = 50). Serum maternal beta(2)-microglobulin was directly correlated with total serum IgG levels in HIV-infected mothers (r = 0.58; P = 0.0002), but not in healthy HIV-seronegative mothers (r = - 0.20; P = 0.16). Maternal serum beta(2)-microglobulin was also inversely correlated with placental antibody transfer of total IgG in mother-newborn pairs from the HIV group (r = 0.38; P = 0.02), but not from the control group (r = 0.15, P = 0.31). These results seem to indicate that, in HIV infection, elevated serum beta(2)-microglobulin levels could be involved in maintenance of abnormally high total serum IgG concentrations; by interfering with the binding of IgG to Fc receptors at the maternal-fetal interface, they might also reduce IgG transfer. By contrast, in normal non-HIV infected individuals: serum beta(2)-microglobulin levels do not appear implicated in regulation of these two phenomena. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
Palavra-chave placental IgG transfer
IgG catabolism
beta(2)-microglobulin
HIV infection
Fc receptor
Idioma Inglês
Data de publicação 1999-03-01
Publicado em Journal of Reproductive Immunology. Clare: Elsevier Sci Ireland Ltd, v. 42, n. 2, p. 167-174, 1999.
ISSN 0165-0378 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 167-174
Fonte http://dx.doi.org/10.1016/S0165-0378(98)00083-7
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000079456900007
Endereço permanente http://repositorio.unifesp.br/handle/11600/26041

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