Differences in central and peripheral responses to oxotremorine in young and aged rats

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dc.contributor.author Espinola, E. B.
dc.contributor.author Oliveira, MGM
dc.contributor.author Carlini, E. A.
dc.date.accessioned 2016-01-24T12:30:46Z
dc.date.available 2016-01-24T12:30:46Z
dc.date.issued 1999-03-01
dc.identifier http://dx.doi.org/10.1016/S0091-3057(98)00192-0
dc.identifier.citation Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 62, n. 3, p. 419-423, 1999.
dc.identifier.issn 0091-3057
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/26040
dc.description.abstract Few studies have investigated the pharmacological response of agents that act on the cholinergic system from the point of view of age. the present article investigated central responses (tremor) and peripheral responses (chromodacryorrhea) subsequent to the administration of oxotremorine to young (3-6 months of age) and aged rats (24-30 months of age). the aged rats presented greater duration and intensity of tremor in three doses utilized (0.25, 0.5, and 1.0 mg/kg) compared to young rats. These two groups of animals did differ in latency for the onset of the tremor. the aged rats presented more intense chromodacryorrhea than the young rats in all utilized doses. These data are indicative that both responses-central and peripheral-are affected by aging, possibly as a result of pharmacokinetic alterations and/or alterations in functionality of the cholinergic system in aged rats. (C) 1999 Elsevier Science Inc. en
dc.format.extent 419-423
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Pharmacology Biochemistry and Behavior
dc.rights Acesso restrito
dc.subject oxotremorine en
dc.subject aging en
dc.subject cholinergic system en
dc.subject tremor en
dc.subject Chromodacryorrhea en
dc.title Differences in central and peripheral responses to oxotremorine in young and aged rats en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Psicobiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psicobiol, BR-04023062 São Paulo, Brazil
dc.identifier.doi 10.1016/S0091-3057(98)00192-0
dc.description.source Web of Science
dc.identifier.wos WOS:000078773300004



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