Differences in central and peripheral responses to oxotremorine in young and aged rats

Differences in central and peripheral responses to oxotremorine in young and aged rats

Autor Espinola, E. B. Google Scholar
Oliveira, MGM Google Scholar
Carlini, E. A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Few studies have investigated the pharmacological response of agents that act on the cholinergic system from the point of view of age. the present article investigated central responses (tremor) and peripheral responses (chromodacryorrhea) subsequent to the administration of oxotremorine to young (3-6 months of age) and aged rats (24-30 months of age). the aged rats presented greater duration and intensity of tremor in three doses utilized (0.25, 0.5, and 1.0 mg/kg) compared to young rats. These two groups of animals did differ in latency for the onset of the tremor. the aged rats presented more intense chromodacryorrhea than the young rats in all utilized doses. These data are indicative that both responses-central and peripheral-are affected by aging, possibly as a result of pharmacokinetic alterations and/or alterations in functionality of the cholinergic system in aged rats. (C) 1999 Elsevier Science Inc.
Palavra-chave oxotremorine
aging
cholinergic system
tremor
Chromodacryorrhea
Idioma Inglês
Data de publicação 1999-03-01
Publicado em Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 62, n. 3, p. 419-423, 1999.
ISSN 0091-3057 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 419-423
Fonte http://dx.doi.org/10.1016/S0091-3057(98)00192-0
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000078773300004
Endereço permanente http://repositorio.unifesp.br/handle/11600/26040

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