C-erbB-2 immunoexpression in parathyroid tumors and hyperplasias

C-erbB-2 immunoexpression in parathyroid tumors and hyperplasias

Autor Kayath, M. J. Google Scholar
Martin, L. C. Google Scholar
Vieira, JGH Google Scholar
Nose, V Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo C-erbB-2 is a proto-oncogene previously implicated in the pathogenesis and prognosis of several human tumors. the authors investigated c-erbB-2 immunoexpression in parathyroid tumors and hyperplasias, and correlated its presence with the diagnosis and severity of the parathyroid lesions. One hundred two parathyroid tissues (28 adenomas, 12 primary hyperplasias, 57 secondary hyperplasias, and 5 carcinomatous tissues) were studied. Membrane c-erbB-2 (either in the cell membrane or on the border of pseudocysts) was absent in normal glands, and detected in 50% of the adenomas, 25% of the primary hyperplasias, 100% of the carcinomas, and 12 and 53% of the secondarily diffuse and nodular hyperplasias, respectively. C-erbB-2 expression was significantly lower in diffuse hyperplasias than in other parathyroid lesions (P < 0.05). Cytoplasmic c-erbB-2 expression (restricted to oxyphil cells) was found in 50% of the normal tissues and in variable frequency in parathyroid lesions. Mean gland mass and intact parathyroid hormone levels were not significantly different according to c-erbB-2 immunodetection. Mean serum ionized calcium was higher in c-erbB-2-positive adenomas than in negative ones (P = 0.006). in conclusion, c-erbB-2 protein is frequently detected in hyperproliferative conditions of the parathyroid, such as neoplasms and hyperplasias.
Palavra-chave parathyroid neoplasms
c :-erbB-2
hyperparathyroidism
Idioma Inglês
Data de publicação 1999-03-01
Publicado em Endocrine Pathology. Totowa: Humana Press Inc, v. 10, n. 1, p. 47-54, 1999.
ISSN 1046-3976 (Sherpa/Romeo, fator de impacto)
Publicador Humana Press Inc
Extensão 47-54
Fonte http://dx.doi.org/10.1007/BF02738815
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000079906100006
Endereço permanente http://repositorio.unifesp.br/handle/11600/26039

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