Different pathways for Ca2+ mobilization by angiotensin II and carbachol in the circular muscle of the guinea-pig ileum

Mostrar registro simples

dc.contributor.author Shimuta, S. I.
dc.contributor.author Borges, ACR
dc.contributor.author Prioste, R. N.
dc.contributor.author Paiva, T. B.
dc.date.accessioned 2016-01-24T12:30:45Z
dc.date.available 2016-01-24T12:30:45Z
dc.date.issued 1999-02-12
dc.identifier http://dx.doi.org/10.1016/S0014-2999(98)00919-4
dc.identifier.citation European Journal of Pharmacology. Amsterdam: Elsevier B.V., v. 367, n. 1, p. 59-66, 1999.
dc.identifier.issn 0014-2999
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/26033
dc.description.abstract Ca2+ pathways activated by angiotensin II and carbachol were evaluated in the circular muscle of the guinea-pig ileum by recording mechanical and electrical activities. Transient contractions induced by angiotensin II were greatly reduced by Ca2+ removal from the medium whereas carbachol-induced responses were not significantly altered. Nifedipine had no effect on the responses to both agonists. A high concentration of tetrodotoxin (0.1 mu M) inhibited angiotensin II-induced contractile responses without affecting the depolarization, whereas 1 mM Ni2+ inhibited the mechanical and electrical effects. Neither tetrodotoxin nor Ni2+ affected carbachol-induced effects. These results indicate that angiotensin II-induced phasic contractions depend on extracellular Ca2+ but not on voltage-dependent L-type Ca2+ channels. It is suggested that angiotensin II activates Ni2+-sensitive Na+ and non-specific cationic channels, whereas the responses to carbachol are dependent on receptor-activated Ca2+ release. Furthermore the different response of the longitudinal and circular muscles to the inhibitory effects of tetrodotoxin and Ni2+ on the angiotensin II- and carbachol-induced contractions indicates that these agonists exert their own myogenic effects on each layer and are able to trigger different Ca2+ mobilization pathways. (C) 1999 Elsevier Science B.V. All rights reserved. en
dc.format.extent 59-66
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof European Journal of Pharmacology
dc.rights Acesso restrito
dc.subject angiotensin II en
dc.subject carbachol en
dc.subject ileal circular muscle en
dc.subject mechanical activity en
dc.subject electrical activity en
dc.subject tetrodotoxin en
dc.subject Ni2+ en
dc.title Different pathways for Ca2+ mobilization by angiotensin II and carbachol in the circular muscle of the guinea-pig ileum en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Biophys, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Biophys, BR-04023062 São Paulo, Brazil
dc.identifier.doi 10.1016/S0014-2999(98)00919-4
dc.description.source Web of Science
dc.identifier.wos WOS:000078672000009



Arquivos deste item

Arquivos Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item aparece na(s) seguinte(s) coleção(s)

Mostrar registro simples