Nephrotic syndrome as a clinical manifestation of graft-versus-host disease (GVHD) in a marrow transplant recipient after cyclosporine withdrawal

Nephrotic syndrome as a clinical manifestation of graft-versus-host disease (GVHD) in a marrow transplant recipient after cyclosporine withdrawal

Autor Oliveira, José Salvador Rodrigues de Autor UNIFESP Google Scholar
Bahia, Daniella Marcia Maranhao Autor UNIFESP Google Scholar
Franco, Marcello Fabiano de Autor UNIFESP Google Scholar
Balda, C. Google Scholar
Stella, S. Google Scholar
Kerbauy, José Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo GVHD is one of the most frequent complications of BMT and recently nephrotic syndrome (NS) has been described as a manifestation of chronic GVHD, Here, we present an AA patient who developed NS 1 year after BMT when cyclosporine was stopped. Renal biopsy showed focal sclerosis associated with membranous deposits. He also had other clinical manifestations of chronic GVHD: sicca-like syndrome and colestasis, After 15 days of CsA therapy, he experienced a remarkable improvement in the NS and GVHD as a whole. We comment on immunological mechanisms that could be involved in the pathogenesis of this manifestation.
Palavra-chave nephrotic syndrome
bone marrow transplant
GVHD
Idioma Inglês
Data de publicação 1999-01-01
Publicado em Bone Marrow Transplantation. Basingstoke: Stockton Press, v. 23, n. 1, p. 99-101, 1999.
ISSN 0268-3369 (Sherpa/Romeo, fator de impacto)
Publicador Stockton Press
Extensão 99-101
Fonte http://dx.doi.org/10.1038/sj.bmt.1701527
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000078318800017
Endereço permanente http://repositorio.unifesp.br/handle/11600/25998

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