Risk factors for severe hemorrhagic cystitis following BMT

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dc.contributor.author Seber, Adriana [UNIFESP]
dc.contributor.author Shu, X. O.
dc.contributor.author Defor, T.
dc.contributor.author Sencer, S.
dc.contributor.author Ramsay, N.
dc.date.accessioned 2016-01-24T12:30:43Z
dc.date.available 2016-01-24T12:30:43Z
dc.date.issued 1999-01-01
dc.identifier http://dx.doi.org/10.1038/sj.bmt.1701523
dc.identifier.citation Bone Marrow Transplantation. Basingstoke: Stockton Press, v. 23, n. 1, p. 35-40, 1999.
dc.identifier.issn 0268-3369
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/25997
dc.description.abstract Hemorrhagic cystitis (HC) is a common toxicity of preparative regimens for bone marrow transplantation (BMT), Severe HC often requires prolonged and expensive hospitalization, and occasionally can result in death. To investigate the risk factors for severe HC, we conducted a retrospective study among 1908 patients who received BMTs at the University of Minnesota during 1974 to 1993, A previous report from our institution reported on 977 of these patients. We identified all patients with genitourinary complication within 100 days post-BMT from the BMT database. Medical charts for these patients were reviewed to determine whether the patient had HC and also the grade of HC, A total of 208 HC cases were identified during the study period. of them, 92 patients had severe HC, an incidence of 5% (95% CI = 4-6%), We found that grade II-IV graft-versus-host disease (RR = 2.56; 95% CI = 1.43-4.56), use of busulfan (RR = 2.69; 95% CI = 1.35-5.35), and age at transplant (RR = 2.20; 95% CI = 1.27-3.81, for age of 10-30 compared to age of 0-9) were related to an increased risk of HC. in contrast, transplant year was inversely associated with the risk of HC (trend test, P < 0.01). We did not find any significant difference in HC with the use of prophylactic Mesna. en
dc.format.extent 35-40
dc.language.iso eng
dc.publisher Stockton Press
dc.relation.ispartof Bone Marrow Transplantation
dc.rights Acesso aberto
dc.subject bone marrow transplantation en
dc.subject complications en
dc.subject hemorrhagic cystitis en
dc.subject risk factors en
dc.subject adenovirus en
dc.subject cytomegalovirus en
dc.title Risk factors for severe hemorrhagic cystitis following BMT en
dc.type Artigo
dc.contributor.institution Univ Minnesota
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Childrens Hlth Care
dc.description.affiliation Univ Minnesota, Blood & Marrow Transplantat Program, Minneapolis, MN 55455 USA
dc.description.affiliation Universidade Federal de São Paulo, Dept Pediat, São Paulo, Brazil
dc.description.affiliation Univ Minnesota, Sch Med, Dept Pediat, Div Pediat Epidemiol & Clin Res, Minneapolis, MN 55455 USA
dc.description.affiliation Childrens Hlth Care, Minneapolis, MN 55455 USA
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Pediat, São Paulo, Brazil
dc.identifier.doi 10.1038/sj.bmt.1701523
dc.description.source Web of Science
dc.identifier.wos WOS:000078318800006



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