Risk factors for severe hemorrhagic cystitis following BMT

Risk factors for severe hemorrhagic cystitis following BMT

Autor Seber, Adriana Autor UNIFESP Google Scholar
Shu, X. O. Google Scholar
Defor, T. Google Scholar
Sencer, S. Google Scholar
Ramsay, N. Google Scholar
Instituição Univ Minnesota
Universidade Federal de São Paulo (UNIFESP)
Childrens Hlth Care
Resumo Hemorrhagic cystitis (HC) is a common toxicity of preparative regimens for bone marrow transplantation (BMT), Severe HC often requires prolonged and expensive hospitalization, and occasionally can result in death. To investigate the risk factors for severe HC, we conducted a retrospective study among 1908 patients who received BMTs at the University of Minnesota during 1974 to 1993, A previous report from our institution reported on 977 of these patients. We identified all patients with genitourinary complication within 100 days post-BMT from the BMT database. Medical charts for these patients were reviewed to determine whether the patient had HC and also the grade of HC, A total of 208 HC cases were identified during the study period. of them, 92 patients had severe HC, an incidence of 5% (95% CI = 4-6%), We found that grade II-IV graft-versus-host disease (RR = 2.56; 95% CI = 1.43-4.56), use of busulfan (RR = 2.69; 95% CI = 1.35-5.35), and age at transplant (RR = 2.20; 95% CI = 1.27-3.81, for age of 10-30 compared to age of 0-9) were related to an increased risk of HC. in contrast, transplant year was inversely associated with the risk of HC (trend test, P < 0.01). We did not find any significant difference in HC with the use of prophylactic Mesna.
Palavra-chave bone marrow transplantation
complications
hemorrhagic cystitis
risk factors
adenovirus
cytomegalovirus
Idioma Inglês
Data de publicação 1999-01-01
Publicado em Bone Marrow Transplantation. Basingstoke: Stockton Press, v. 23, n. 1, p. 35-40, 1999.
ISSN 0268-3369 (Sherpa/Romeo, fator de impacto)
Publicador Stockton Press
Extensão 35-40
Fonte http://dx.doi.org/10.1038/sj.bmt.1701523
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000078318800006
Endereço permanente http://repositorio.unifesp.br/handle/11600/25997

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