Increased ACTH and corticosterone secretion induced by different methods of paradoxical sleep deprivation

Increased ACTH and corticosterone secretion induced by different methods of paradoxical sleep deprivation

Autor Suchecki, Deborah Autor UNIFESP Google Scholar
Lobo, Leticia Leite Autor UNIFESP Google Scholar
Hipólide, Débora Cristina Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The methods used to induce paradoxical sleep (PS) deprivation are believed to be stressful. in the present study, two methods were compared in regard to their ability to activate the hypothalamic-pituitary-adrenal (HPA) axis. Animals were placed on multiple large (MLP) or small (MSP) platforms or on single large (SLP) or small (SSP) platforms and blood sampled at the end of a 4-day period of PS deprivation (experiment 1) or on Days 1 (short-term) and 1 (long-term) of PS deprivation (experiment 2). ACTH and corticosterone (CORT) levels were determined by RIA. the results of experiment 1 showed that all experimental animals presented increased ACTH response, compared to controls. CORT levels, however, were only elevated in MSP animals, suggesting increased adrenal sensitivity. Experiment 2 showed that ACTH levels of MSP animals were higher than MLP and SSP animals, and that animals placed on the multiple platform tanks showed the highest ACTH levels on Day 4 of manipulation. CORT levels were elevated in the animals kept over small platforms. and these levels where higher on Day 1 than basal and further elevated on Day 4 of PS deprivation. These results indicate that the multiple platform technique induces a distinct activation of the I-IPA axis, and that PS deprivation may act as an additional stressor.
Palavra-chave ACTH
corticosterone
paradoxical sleep deprivation
hypothalamic-pituitary-adrenal axis
rats
stress
Idioma Inglês
Data de publicação 1998-12-01
Publicado em Journal of Sleep Research. Oxford: Blackwell Science Ltd, v. 7, n. 4, p. 276-281, 1998.
ISSN 0962-1105 (Sherpa/Romeo, fator de impacto)
Publicador Blackwell Science Ltd
Extensão 276-281
Fonte http://dx.doi.org/10.1046/j.1365-2869.1998.00122.x
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000077283500007
Endereço permanente http://repositorio.unifesp.br/handle/11600/25982

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