Ribosomal RNA in Alzheimer's disease and ageing

Ribosomal RNA in Alzheimer's disease and ageing

Autor Payao, SLM Google Scholar
Smith, MDC Google Scholar
Winter, LPF Google Scholar
Bertolucci, PHF Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo Ribosomal RNA genes are involved in cell transcription and translation processes and can modulate gene expression. in an earlier cytogenetic study,(Payao, S.L.M., Smith, M.de A.C., Kormann-Bortolotto, M.H., Toniolo, J., 1994 (Investigation of the nucleolar organizer regions in Alzheimer's disease. Gerontology 40, 13-17), reported a decreased activity of ribosomal genes in Alzheimer's disease (AD). We studied the ratio of mature rRNA 28S and 18S in peripheral blood samples derived from eight patients with AD, eight healthy elderly sisters of these patients (SA), eight healthy elderly (EC) and eight healthy young (YC) controls, all female. Our results showed a statistically significant decrease of mature rRNA 28S and 18S ratio in the elderly groups (AD, SA, EC) in relation to the young one, probably by fragmentation of 28S rRNA. the Alzheimer's patient group had the lowest 28S/18S ratio. Thus, we can suggest that there is a possible change in the transcriptional or maturation process, or a preferential degradation of the 28S subunit with ageing. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
Assunto Alzheimer's disease
Idioma Inglês
Data 1998-11-16
Publicado em Mechanisms of Ageing and Development. Clare: Elsevier Sci Ireland Ltd, v. 105, n. 3, p. 265-272, 1998.
ISSN 0047-6374 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 265-272
Fonte http://dx.doi.org/10.1016/S0047-6374(98)00095-5
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000077270200005
URI http://repositorio.unifesp.br/handle/11600/25979

Mostrar registro completo

Arquivos deste item

Arquivos Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item aparece na(s) seguinte(s) coleção(s)