Ribosomal RNA in Alzheimer's disease and ageing

Ribosomal RNA in Alzheimer's disease and ageing

Author Payao, SLM Google Scholar
Smith, MDC Google Scholar
Winter, LPF Google Scholar
Bertolucci, PHF Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Ribosomal RNA genes are involved in cell transcription and translation processes and can modulate gene expression. in an earlier cytogenetic study,(Payao, S.L.M., Smith, M.de A.C., Kormann-Bortolotto, M.H., Toniolo, J., 1994 (Investigation of the nucleolar organizer regions in Alzheimer's disease. Gerontology 40, 13-17), reported a decreased activity of ribosomal genes in Alzheimer's disease (AD). We studied the ratio of mature rRNA 28S and 18S in peripheral blood samples derived from eight patients with AD, eight healthy elderly sisters of these patients (SA), eight healthy elderly (EC) and eight healthy young (YC) controls, all female. Our results showed a statistically significant decrease of mature rRNA 28S and 18S ratio in the elderly groups (AD, SA, EC) in relation to the young one, probably by fragmentation of 28S rRNA. the Alzheimer's patient group had the lowest 28S/18S ratio. Thus, we can suggest that there is a possible change in the transcriptional or maturation process, or a preferential degradation of the 28S subunit with ageing. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
Keywords Alzheimer's disease
Language English
Date 1998-11-16
Published in Mechanisms of Ageing and Development. Clare: Elsevier Sci Ireland Ltd, v. 105, n. 3, p. 265-272, 1998.
ISSN 0047-6374 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 265-272
Origin http://dx.doi.org/10.1016/S0047-6374(98)00095-5
Access rights Closed access
Type Article
Web of Science ID WOS:000077270200005
URI http://repositorio.unifesp.br/handle/11600/25979

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