Persistence and atrophy of septal/diagonal band neurons expressing the p75 neurotrophin receptor in pilocarpine-induced chronic epilepsy in the rat

Persistence and atrophy of septal/diagonal band neurons expressing the p75 neurotrophin receptor in pilocarpine-induced chronic epilepsy in the rat

Autor Correia, L. Google Scholar
Amado, D. Google Scholar
Cavalheiro, E. A. Google Scholar
Bentivoglio, M. Google Scholar
Instituição Univ Verona
Universidade Federal de São Paulo (UNIFESP)
Resumo Systemic administration of pilocarpine, which results in status epilepticus followed by recurrent seizures in rats, is a widely used experimental model of chronic limbic epilepsy. Marked structural alterations have been documented in pilocarpine-induced epilepsy, and these include cell loss in the hippocampus and other brain areas, and sprouting of mossy and cholinergic fibers in the hippocampus. Evidence is accumulating that neurotrophins and neurotrophin receptors are involved in the cascade of these events. Two and 4 months after pilocarpine-induced epilepsy, neurons containing the 75-kDa low affinity neurotrophin receptor (p75(NTR)) were investigated with immunohistochemistry in the medial septal and diagonal band nuclei. No significant differences in the distribution and number of immunoreactive neurons were found in the epileptic rats compared to control saline-treated animals. However, in the epileptic animals, a significant decrease in the perikaryal size of p75(NTR)-immunoreactive neurons of the septal/diagonal band region was found by 60 days, and such atrophic changes were more marked in the diagonal band nuclei by 120 days. These findings indicate that the p75(NTR)-containing cell bodies, which include the neurons projecting to the hippocampal formation and are cholinergic in the normal brain, survive after months of spontaneous recurrent seizures, during which, therefore, a supply of p75NTR to target regions is maintained in the chronic epileptic brain. However, the present data point out that these p75NTR-containing neurons undergo a significant shrinkage in pilocarpine-induced chronic epilepsy, thus indicating that they are involved in the brain pathology of temporal lube epilepsy. (C) 1998 Elsevier Science B.V. All rights reserved.
Palavra-chave temporal lobe epilepsy
neurotrophin
septohippocampal neuron
forebrain cholinergic neuron
hippocampus
Idioma Inglês
Data de publicação 1998-11-02
Publicado em Brain Research. Amsterdam: Elsevier B.V., v. 809, n. 2, p. 288-293, 1998.
ISSN 0006-8993 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 288-293
Fonte http://dx.doi.org/10.1016/S0006-8993(98)00871-3
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000076722500018
Endereço permanente http://repositorio.unifesp.br/handle/11600/25978

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