Azole resistance among oral Candida species isolates from AIDS patients under ketoconazole exposure

Azole resistance among oral Candida species isolates from AIDS patients under ketoconazole exposure

Autor Milan, E. P. Google Scholar
Burattini, M. N. Google Scholar
Kallas, E. G. Google Scholar
Fischmann, O. Google Scholar
Costa, PRD Google Scholar
Colombo, A. L. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Hosp Servidor Publ Estadual Francisco Moratto de
Univ Fed Rio Grande Norte
Resumo This is a prospective study designed to investigate species distribution and azole susceptibility profile among Candida spp. isolated from the oral cavities of AIDS patients. One hundred thirty-two AIDS patients sequentially admitted at a teaching tertiary care hospital were enrolled in this study. Samples were obtained by swabbing the oral cavities of the patients. Yeast isolates were identified by classical methods and the antifungal susceptibility profile was further determined according to the NCCLS microbroth assay. Among all patients with prescriptions of systemic antifungal drugs, ketoconazole had been elected to treat 56% of patients. We found 82% of oral yeast carriage, 22% of them harboring non-albicans species. Overall rates of susceptibility dose dependent/resistance to azoles was 16% for itraconazole, 13% for ketoconazole, and 10% for fluconazole with a high agreement rate among the susceptibility profiles of all isolates tested against the triazoles. (C) 1998 Elsevier, Science Inc.
Idioma Inglês
Data 1998-11-01
Publicado em Diagnostic Microbiology and Infectious Disease. New York: Elsevier B.V., v. 32, n. 3, p. 211-216, 1998.
ISSN 0732-8893 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 211-216
Fonte http://dx.doi.org/10.1016/S0732-8893(98)00107-2
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000077786800012
URI http://repositorio.unifesp.br/handle/11600/25973

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