Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: A qualitative study

Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: A qualitative study

Autor Scorza, Fulvio Alexandre Autor UNIFESP Google Scholar
Sanabria, ERG Google Scholar
Calderazzo, Lineu Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrão Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Purpose: Interictal intervals in pilocarpine-induced chronic epilepsy are characterized by apparent normal electrographic activity and longer sleep periods or drowsiness or both. Sparse information exists concerning the neural network activity during these seizure-free intervals. in our research, all [C-14]2-deoxy-D-glucose (2DG) autoradiographic technique was used to investigate interictal changes in the metabolism of the epileptic rat brain.Methods: Epileptic mts were monitored by video-EEG for similar to 120 days, with [C-14]2DG injected after a seizure-free interval of greater than or equal to 24 h.Results: Autoradiographic analysis revealed an increase in glucose utilization by several brain regions; the most consistent increase was found in the lateral posterior thalamic nucleus and prerectal region.Conclusions: These findings suggest that the lateral posterior thalamic nucleus and the prerectal region may be involved in cerebral circuits inhibiting epileptic activity during interictal intervals.
Palavra-chave interictal
pilocarpine
epilepsy
deoxyglucose
rat
Idioma Inglês
Data de publicação 1998-10-01
Publicado em Epilepsia. Philadelphia: Lippincott Williams & Wilkins, v. 39, n. 10, p. 1041-1045, 1998.
ISSN 0013-9580 (Sherpa/Romeo, fator de impacto)
Publicador Lippincott Williams & Wilkins
Extensão 1041-1045
Fonte http://dx.doi.org/10.1111/j.1528-1157.1998.tb01288.x
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000076280500002
Endereço permanente http://repositorio.unifesp.br/handle/11600/25961

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