Reserpine does not induce orofacial dyskinesia in spontaneously hypertensive rats

Reserpine does not induce orofacial dyskinesia in spontaneously hypertensive rats

Autor Queiroz, CMT Google Scholar
Piovezan, R. D. Google Scholar
Frussa-Filho, R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The nigrostriatal dopaminergic system seems to be involved in both reserpine-induced orofacial dyskinesia in normal rats and in the pathogenesis of hypertension in spontaneously hypertensive rats. in the present study, repeated reserpine administration (1.0 mg/kg, s.c., every other day, for 3 days) increased tongue protrusion and vacuous chewing frequencies as well as the duration of facial twitching in Wistar normotensive but not in spontaneously hypertensive rats. These results suggest that genetic hypertension and drug-induced orofacial movements may be inversely modulated by similar mechanisms in the nigrostriatal dopaminergic system. (C) 1998 Elsevier Science B.V. All rights reserved.
Palavra-chave reserpine
spontaneously hypertensive rat (SHR)
orofacial dyskinesia
tardive dyskinesia
dopamine
Idioma Inglês
Data de publicação 1998-09-04
Publicado em European Journal of Pharmacology. Amsterdam: Elsevier B.V., v. 356, n. 2-3, p. 105-108, 1998.
ISSN 0014-2999 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 105-108
Fonte http://dx.doi.org/10.1016/S0014-2999(98)00546-9
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000076065500002
Endereço permanente http://repositorio.unifesp.br/handle/11600/25957

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