Hormonal and gestational parameters in female rats submitted to the pilocarpine model of epilepsy

Hormonal and gestational parameters in female rats submitted to the pilocarpine model of epilepsy

Autor Amado, D. Google Scholar
Cavalheiro, E. A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Endocrine and reproductive alterations are frequently reported to occur in women with temporal lobe epilepsy as well as in female rats in different experimental models of limbic seizures. As previously reported, women with epilepsy have lower fertility rates than women without epilepsy (Tanganelli, P., Regesta, G., 1992. Neurology (suppl.) 42 (5), 89-93; Cummings, L.N., Guidice, L., Morrel, M.J., 1995. Epilepsia 36, 355-359). in order to investigate the possible substrate of endocrine alterations in epilepsy, hormonal and gestational parameters were studied in female rats submitted to the pilocarpine model of epilepsy. the results demonstrated that the oestrus cycle is altered following pilocarpine-induced status epilepticus and such alteration lasted for several weeks. Progesterone, LH and FSH levels decreased and estradiol levels increased si,significantly during the period of spontaneous and recurrent seizures. the frequency of seizures during pregnancy and lactation decreased. These results document that significant changes in gonadal, hypophyseal and hypothalamic hormones, as well as in sexual behaviour, occur following status epilepticus induced by pilocarpine administration. (C) 1998 Elsevier Science B.V. All rights reserved.
Palavra-chave epilepsy
hormonal dysfunction
hypothalamus
limbic seizures
pregnancy
reproductive hormones
Idioma Inglês
Data de publicação 1998-09-01
Publicado em Epilepsy Research. Amsterdam: Elsevier B.V., v. 32, n. 1-2, p. 266-274, 1998.
ISSN 0920-1211 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 266-274
Fonte http://dx.doi.org/10.1016/S0920-1211(98)00057-6
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000076034000024
Endereço permanente http://repositorio.unifesp.br/handle/11600/25955

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