Supragranular mossy fiber sprouting is not necessary for spontaneous seizures in the intrahippocampal kainate model of epilepsy in the rat

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dc.contributor.author Longo, B. M.
dc.contributor.author Mello, LEAM
dc.date.accessioned 2016-01-24T12:30:39Z
dc.date.available 2016-01-24T12:30:39Z
dc.date.issued 1998-09-01
dc.identifier http://dx.doi.org/10.1016/S0920-1211(98)00049-7
dc.identifier.citation Epilepsy Research. Amsterdam: Elsevier B.V., v. 32, n. 1-2, p. 172-182, 1998.
dc.identifier.issn 0920-1211
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/25954
dc.description.abstract In a previous study, we suggested a dissociation between spontaneous recurrent epileptic seizures (SRS) and hippocampal supragranular mossy fiber sprouting (MFS) in the pilocarpine model of epilepsy (PILO). One possible explanation, would be that SRS in the PILO model do not originate in the hippocampus and thus would not depend on MFS. Tn the present study, we investigated whether MFS is necessary for the SRS that develop after a small intrahippocampal dose of kainic acid (KA), a model where seizures are more likely to start in the hippocampus. Intrahippocampal injections of ECA were performed in rats, with and without the concomitant administration of cycloheximide (CHX) (0.5 mu g of KA and 6 mu g of CHX). After injection, recording electrodes were positioned in the same stereotaxic location. Hen again, CHX was able to completely block (5/8 animals) MFS, visualized by neo-Timm staining, without altering the frequency and intensity of spontaneous ictal and interictal EEG events. From these data, we can conclude that, in the intra-hippocampal KA model, MFS is not necessary for the occurrence of ictal events. We suggest that CHX can be used together with classic epileptogenic agents, as a means to study temporal lobe epilepsy (TLE) without the contributing effect of MFS-as seen in TLE patients with mass lesions in the lateral temporal lobe. (C) 1999 Elsevier Science B.V. All rights reserved. en
dc.format.extent 172-182
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Epilepsy Research
dc.rights Acesso restrito
dc.subject supragranular mossy fiber en
dc.subject seizure en
dc.subject temporal lobe en
dc.title Supragranular mossy fiber sprouting is not necessary for spontaneous seizures in the intrahippocampal kainate model of epilepsy in the rat en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Physiol, EPM, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Physiol, EPM, BR-04023900 São Paulo, Brazil
dc.identifier.doi 10.1016/S0920-1211(98)00049-7
dc.description.source Web of Science
dc.identifier.wos WOS:000076034000016



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