Sleep deprivation induces brain region-specific decreases in glutathione levels

Sleep deprivation induces brain region-specific decreases in glutathione levels

Autor D'Almeida, V Google Scholar
Lobo, L. L. Google Scholar
Hipolide, D. C. Google Scholar
Oliveira, A. C. de Google Scholar
Nobrega, J. N. Google Scholar
Tufik, S. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Clarke Inst Psychiat
Resumo RATS were deprived of sleep for 96 h by the platform technique and total glutathione (GSH tau) levels were measured in seven different brain areas. Glutathione levels were found to be significantly reduced in the hypothalamus of sleep-deprived animals when compared with large platform (-18%) or home cage (-31%) controls. Deprived rats also had reduced GSH tau levels in thalamus compared with home cage controls only. Glutathione levels did not differ among the three groups in any of the other brain areas examined. These results indicate that specific brain areas may be differentially susceptible to oxidative stress after sleep deprivation. the apparent vulnerability of the hypothalamus to these effects may contribute to some of the functional effects of sleep deprivation. (C) 1998 Lippincott Williams & Wilkins.
Palavra-chave antioxidants
glutathione
hypothalamus
oxidative stress
sleep deprivation
Idioma Inglês
Data de publicação 1998-08-24
Publicado em Neuroreport. Philadelphia: Lippincott Williams & Wilkins, v. 9, n. 12, p. 2853-2856, 1998.
ISSN 0959-4965 (Sherpa/Romeo, fator de impacto)
Publicador Lippincott Williams & Wilkins
Extensão 2853-2856
Fonte http://dx.doi.org/10.1097/00001756-199808240-00031
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000076184100033
Endereço permanente http://repositorio.unifesp.br/handle/11600/25940

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