Effect of etidronate treatment on bone mass of male nephrolithiasis patients with idiopathic hypercalciuria and osteopenia

Effect of etidronate treatment on bone mass of male nephrolithiasis patients with idiopathic hypercalciuria and osteopenia

Author Heilberg, I. P. Google Scholar
Martini, L. A. Google Scholar
Teixeira, S. H. Google Scholar
Szejnfeld, V. L. Google Scholar
Carvalho, A. B. Google Scholar
Lobao, R. Google Scholar
Draibe, S. A. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Osteopenia is frequently found among calcium stone forming (CSF) patients with hypercalciuria. We investigated the effect of a 2-year therapeutic course of etidronate, a bone-sparing agent, in 7 young male CSF patients. the treatment consisted of a cyclic intermittent administration of phosphate followed by sodium etidronate and calcium supplementation every 74 days. Bone mineral density (BMD) measured at 12-month intervals and bone biopsies performed at baseline and after 2 years were the primary efficacy parameters. Mean lumbar spine BMD increased significantly after the 1st year by 2.6 +/- 1.0% (mean +/- SE, p < 0.05) and nonsignificantly after the 2nd year by 5.6 +/- 2.6 %. Nonsignificant changes were observed for femoral neck mean BMD after either the 1st or the 2nd year (decrease of 2.0 +/- 1.0% and 2.0 +/- 3.0%, respectively). Mean histomorphometric parameters showed that bone volume, osteoid volume, and eroded surfaces did not differ from baseline (13.9 +/- 2.2 vs. 12.2 +/- 1.1%, 1.2 +/- 0.7 vs. 2.6 +/- 0.7%, and 20.7 +/- 6.2 vs. 13.7 +/- 1.3%, respectively). Osteoid surface was significantly lower than baseline values (9.5 +/- 5.2 vs. 18.8 +/- 5.3%, p < 0.05). These data suggest that etidronate given to young male CSF patients presenting with hypercalciuria and osteopenia led to a significant amelioration of BMD, evident only in the lumbar spine after 1 year of treatment. There was no histological evidence of long-term improvement in bone remodeling.
Keywords bisphosphonate
urinary calcium
Language English
Date 1998-08-01
Published in Nephron. Basel: Karger, v. 79, n. 4, p. 430-437, 1998.
ISSN 0028-2766 (Sherpa/Romeo, impact factor)
Publisher Karger
Extent 430-437
Origin http://dx.doi.org/10.1159/000045089
Access rights Closed access
Type Article
Web of Science ID WOS:000075230300007
URI http://repositorio.unifesp.br/handle/11600/25937

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