HLA antigens and haplotypes in IgA-deficient Brazilian paediatric patients

HLA antigens and haplotypes in IgA-deficient Brazilian paediatric patients

Autor Gerbase-Delima, M. Google Scholar
Pinto, L. C. Google Scholar
Grumach, A. Google Scholar
Carneiro-Sampaio, MMS Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo In the present study we determined the HLA-A, B and DR antigenic and haplotypic frequencies in unrelated Brazilian Caucasian paediatric patients with IgA deficiency (IgA-D). Out of 17 IgA-D subjects typed for HLA A and B specificities, 12 (71%) presented B8 and/or B14; of 15 patients also typed for HLA-DR specificities, 14 (93%) were positive for at least one of the HLA markers previously reported to be associated with IgA-D, i.e. B8, B14, DR1, DR3 or DR7. the haplotypes B8, DR3, B14, DR1 and B13, DR7 were present in 43, 21 and 14% of the cases, respectively, while they have a frequency in the general population of 2, 2 and 1%, respectively. the concomitant association with the three IgA-associated haplotypes found in our study probably reflects the admixture of European genetic influences present in the Brazilian Caucasian population of S (a) over tilde o Paulo.
Idioma Inglês
Data de publicação 1998-08-01
Publicado em European Journal of Immunogenetics. Oxford: Blackwell Science Ltd, v. 25, n. 4, p. 281-285, 1998.
ISSN 0960-7420 (Sherpa/Romeo, fator de impacto)
Publicador Blackwell Science Ltd
Extensão 281-285
Fonte http://dx.doi.org/10.1046/j.1365-2370.1998.00098.x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000075790000002
Endereço permanente http://repositorio.unifesp.br/handle/11600/25935

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