Dietary magnesium improves endothelial dependent relaxation of balloon injured arteries in rats

Dietary magnesium improves endothelial dependent relaxation of balloon injured arteries in rats

Autor Fonseca, Francisco AH Google Scholar
Paiva, Therezinha B. Google Scholar
Silva, Eneida G. Google Scholar
Ihara, Silvia SM Google Scholar
Kasinski, Nelson Google Scholar
Martinez, Tania LR Google Scholar
Martinez Filho, Eulogio Emilio Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The purpose of the present study was to examine the importance of magnesium in endothelial function after arterial balloon injury. Male Wistar rats were fed normal, high or low concentrations of magnesium. Three weeks later the animals underwent endothelial injury of the thoracic aorta by a balloon catheter or a sham operation. Biochemical, histological and endothelial function analysis were performed 15 days after the surgical treatment. the animals fed a low magnesium diet presented the lowest level of serum magnesium and the highest ionized blood calcium levels. Histomorphometric analysis revealed no differences among groups neither regarding the magnitude of intimal thickening nor the recovery of endothelial coverage. However, when vasoreactivity responses were compared in the balloon-injured group, those animals fed a high magnesium diet had the better endothelium-dependent vascular relaxation. in conclusion, a higher magnesium level in the diet was beneficial to vessels that underwent endothelial injury by balloon catheter. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
Palavra-chave magnesium
balloon-injury
endothelium
endothelium-derived relaxing factor
Idioma Inglês
Data de publicação 1998-08-01
Publicado em Atherosclerosis. Clare: Elsevier Sci Ireland Ltd, v. 139, n. 2, p. 237-242, 1998.
ISSN 0021-9150 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 237-242
Fonte http://dx.doi.org/10.1016/S0021-9150(98)00069-0
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000075128000004
Endereço permanente http://repositorio.unifesp.br/handle/11600/25933

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