Mechanisms of non-adrenergic non-cholinergic synaptic transmission in smooth muscle cells of the gastrointestinal tract

Mechanisms of non-adrenergic non-cholinergic synaptic transmission in smooth muscle cells of the gastrointestinal tract

Autor Shuba, M. F. Google Scholar
Vladimirova, I. A. Google Scholar
Ermakova, T. O. Google Scholar
Jurkiewicz, N. Google Scholar
Jurkiewicz, A. Google Scholar
Instituição Natl Acad Sci Ukraine
Universidade Federal de São Paulo (UNIFESP)
Resumo Non-adrenergic non-cholinergic (NANCh) inhibitory synaptic potentials in smooth muscle cells (SMC) of the gastrointestinal tract are of a complex transmitter and ion nature. A blocker of ATP receptors, suramin, blocks the Fast component, while a blocker of NO synthase, L-NOARG, blocks the slow component of NANCh inhibitory synaptic potentials. in the presence of both suramin and L-NOARG, SMC respond to stimulation of the intramural plexus by generating it low-amplitude hyperpolarization, and VIP is likely to be the transmitter for this effect. Low-conductance Ca2+-dependent potassium channels are involved in generation of the fast component of NANCh Low-conductance Ca inhibitory synaptic potentials, and these channels am effectively blocked by apamin. the slow component of this potential is generated by high-conductance Ca2+-dependent potassium channels. in the presence of both apamin and L-NOARG (or charibdotoxin), SMC respond to intramural stimulations with non-cholinergic excitatory synaptic potentials, and ATP application evokes depolarization. Both effects are blocked by suramin. in the presence of apamin, noradrenaline also evokes depolarization in SMC, and this effect, similarly to hyperpolarization under normal conditions, is blocked by phentolamine. Our studies allow us to suggest that in smooth muscles of the gastrointestinal tract there are two types of synaptic transmission: the excitatory cholinergic, adrenergic, and ATP-ergic transmission and the inhibitory adrenergic, ATP-ergic, NO-ergic, and VIP-ergic transmission.
Idioma Inglês
Data de publicação 1998-07-01
Publicado em Neurophysiology. New York: Plenum Publ Corp, v. 30, n. 4-5, p. 208-212, 1998.
ISSN 0090-2977 (Sherpa/Romeo, fator de impacto)
Publicador Plenum Publ Corp
Extensão 208-212
Fonte http://dx.doi.org/10.1007/BF02462818
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000081217100006
Endereço permanente http://repositorio.unifesp.br/handle/11600/25923

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