Inflammatory response after myocardial revascularization with or without cardiopulmonary bypass

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dc.contributor.author Brasil, Luiz A. [UNIFESP]
dc.contributor.author Gomes, Walter J. [UNIFESP]
dc.contributor.author Salomão, Reinaldo [UNIFESP]
dc.contributor.author Buffolo, Enio [UNIFESP]
dc.date.accessioned 2016-01-24T12:30:36Z
dc.date.available 2016-01-24T12:30:36Z
dc.date.issued 1998-07-01
dc.identifier http://dx.doi.org/10.1016/S0003-4975(98)00181-7
dc.identifier.citation Annals of Thoracic Surgery. New York: Elsevier B.V., v. 66, n. 1, p. 56-59, 1998.
dc.identifier.issn 0003-4975
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/25915
dc.description.abstract Background. Tumor necrosis factor-alpha has been implicated in complications seen after cardiac operations with cardiopulmonary bypass. the release of tumor necrosis factor-alpha and its possible effects were studied in patients undergoing coronary artery bypass grafting with and without cardiopulmonary bypass.Methods. Twenty patients were studied, 10 with (group 1) and 10 without cardiopulmonary bypass (group 2). Serial blood samples were obtained before, during and up to 48 hours after operation. Circulating tumor necrosis factor-alpha levels, leukocyte counts, and erythrocyte sedimentation rates were measured. Hemodynamic variables (blood pressure and heart rate), temperature, orotracheal intubation time, postoperative bleeding, and inotropic drug requirements were compared.Results, Serum levels of tumor necrosis factor-alpha were detected in 6 patients (60%) in group 1 and none in group 2. the patients in group 1 had more hypotension than those in group 2 (7.4 +/- 1.0 mm Hg versus 8.5 +/- 0.7 mm Hg), required more inotropic drugs (8 patients versus 1 patient), and had a higher heart rate (114 +/- 8 beats per minute versus 98 +/- 10 beats per minute), a higher temperature (37.1 degrees +/- 0.5 degrees C versus 36.6 degrees +/- 0.3 degrees C), increased postoperative bleeding (820 +/- 120 mL versus 360 +/- 84 mL), a longer orotracheal intubation time (13.6 +/- 2.2 hours versus 9.3 +/- 1.4 hours), and a more pronounced leukocytosis.Conclusions. Cardiopulmonary bypass induces the whole-body inflammatory response through the release of tumor necrosis factor ct, resulting in adverse systemic effects, (Ann Thorac Surg 1998;66:56-9) (C) 1998 by the Society of Thoracic Surgeons. en
dc.format.extent 56-59
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Annals of Thoracic Surgery
dc.rights Acesso aberto
dc.title Inflammatory response after myocardial revascularization with or without cardiopulmonary bypass en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Discipline Cardiovasc Surg, BR-04023900 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Discipline Infect Dis, BR-04023900 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, São Paulo Hosp, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Discipline Cardiovasc Surg, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Discipline Infect Dis, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, São Paulo Hosp, BR-04023900 São Paulo, Brazil
dc.identifier.doi 10.1016/S0003-4975(98)00181-7
dc.description.source Web of Science
dc.identifier.wos WOS:000074992000014



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