Physiological, hormonal, and behavioral response to a single fentanyl dose in intubated and ventilated preterm neonates

Physiological, hormonal, and behavioral response to a single fentanyl dose in intubated and ventilated preterm neonates

Author Guinsburg, Ruth Autor UNIFESP Google Scholar
Kopelman, B. I. Google Scholar
Anand, KJS Google Scholar
Almeida, MFB de Google Scholar
Peres, C. D. Google Scholar
Miyoshi, M. H. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Emory Univ
Abstract Objective: To study the responses of ventilated preterm neonates to a single dose of opioid.Study design: in a randomized, double-blind, controlled trial, 22 mechanically ventilated preterm infants (less than or equal to 32 weeks) were observed before medication and at 30 and 60 minutes after administration of fentanyl (3 mu g/kg) or placebo. Heart rate, blood pressure, arterial blood gases, ventilator settings, and behavioral measures (Neonatal Facial Coding System and Modified Postoperative Comfort Score) were recorded during each period. Blood cortisol, growth hormone, glucose, and lactate were measured before and at 60 minutes after analgesia. Behavioral measures were assessed at the bedside and from video films recorded during each observation period.Results: Patients presented high basal levels of cortisol, growth hormone, and lactate. Behavioral scales indicated the presence of pain before any medication. in the fentanyl group, the maximum and minimum heart rate decreased and growth hormone level increased after analgesia. At the video analysis of behav;oral measures, postoperative comfort score increased and neonatal facial coding system score decreased in the fentanyl group.Conclusion: Single doses of fentanyl analgesia can reduce the physiologic/behavioral measures of pain and stress associated with mechanical ventilation in preterm infants.
Language English
Date 1998-06-01
Published in Journal of Pediatrics. New York: Mosby-Elsevier, v. 132, n. 6, p. 954-959, 1998.
ISSN 0022-3476 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 954-959
Origin http://dx.doi.org/10.1016/S0022-3476(98)70390-7
Access rights Closed access
Type Article
Web of Science ID WOS:000074065100010
URI http://repositorio.unifesp.br/handle/11600/25905

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