Decreased activity of striatal monoamine oxidase B after rapid eye movement (REM) sleep deprivation in rats

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dc.contributor.author Perez, N. M.
dc.contributor.author Mattei, Rita
dc.contributor.author Venditti, Marco Antonio Campana [UNIFESP]
dc.date.accessioned 2016-01-24T12:30:34Z
dc.date.available 2016-01-24T12:30:34Z
dc.date.issued 1998-05-01
dc.identifier http://dx.doi.org/10.1016/S0091-3057(97)00556-X
dc.identifier.citation Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 60, n. 1, p. 33-37, 1998.
dc.identifier.issn 0091-3057
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/25892
dc.description.abstract The striatum seems to be the main brain region involved in stereotyped behavior induced by dopaminergic agonists. Rapid eye movement (REM) sleep deprivation increases dopaminergic agonist-induced stereotypy and produces biochemical changes in striatal dopaminergic neurotransmission. However, the mechanism underlying the increased dopaminergic sensitivity induced by REM sleep deprivation has not been elucidated. in an attempt to determine some of the biochemical changes in striatal dopaminergic neurotransmission that could contribute to REM sleep deprivation effects, we measured the activity of monoamine oxidase (MAO) A and B, the enzymes responsible for dopamine and beta-phenylethylamine (beta-PEA) deamination in striatum. Male adult rats were deprived of REM sleep for 96 h by the newer-pot technique. MAO A and B were assayed radioisotopically in the mitochondrial fraction by standard laboratory procedures, using [C-14]-5-hydroxytryptamine (5-MT) and [C-14]-beta-phenylethylamine (beta-PEA), as substrates for MAO A and MAO B, respectively. the results showed no significant statistical differences in striatal MAO A activity, whereas a significant decrease in MAO B activity was observed. the results are discussed in terms of the possible involvement of beta-PEA, a striatal endogenous trace amine, which potentiates dopaminergic neurotransmission and may participate in the increased dopaminergic sensitivity observed after REM sleep deprivation. (C) 1998 Elsevier Science Inc. en
dc.format.extent 33-37
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Pharmacology Biochemistry and Behavior
dc.rights Acesso restrito
dc.subject REM sleep deprivation en
dc.subject striatum en
dc.subject monoamine oxidases en
dc.subject tyrosine hydroxylase en
dc.title Decreased activity of striatal monoamine oxidase B after rapid eye movement (REM) sleep deprivation in rats en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Psicobiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Psicobiol, BR-04023062 São Paulo, Brazil
dc.identifier.doi 10.1016/S0091-3057(97)00556-X
dc.description.source Web of Science
dc.identifier.wos WOS:000073551900006



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