Inappropriate prescribing of compounded antiobesity formulas in Brazil

Inappropriate prescribing of compounded antiobesity formulas in Brazil

Author Nappo, S. A. Google Scholar
De Oliveira, E. M. Google Scholar
Morosini, S. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Pernambuco (UFPE)
Abstract Volunteers posing as patients underwent paid medical consultations at the offices of 107 Brazilian doctors (in two Brazilian cities) with the purpose of obtaining an antiobesity prescription. in 80.3% of 71 São Paulo visits, as well as in 47.2% of 36 Recife visits, compounded preparations were prescribed. Four to six active components predominated, but there were prescriptions listing as many as 17 components. All contained anorectic substances and benzodiazepines. Diuretics, thyroid agents, laxatives, medicinal plants, and a variety of other substances were often included. the prescribed doses were frequently above recommended limits, reaching amounts as much as live times the internationally defined standard doses. in some instances two anorectic substances were prescribed simultaneously. Most doctors failed to warn volunteers of the possible occurrence of adverse reactions to the prescribed substances. Furthermore, in the case of all volunteers involved, antiobesity prescriptions would be completely unnecessary, a fact that points to improper medical conduct on the part of doctors. It is concluded that the practice by some Brazilian medical doctors of prescribing manipulation formulas based on anorectic and benzodiazepine drugs is a greater hazard than a benefit to patients. (C) 1998 John Wiley & Sons, Ltd.
Keywords medical prescription
antiobesity drugs
anorectic drugs
magistral formulas
d-fenfluramine weight-reducing drugs
Language English
Date 1998-05-01
Published in Pharmacoepidemiology and Drug Safety. W Sussex: John Wiley & Sons Ltd, v. 7, n. 3, p. 207-212, 1998.
ISSN 1053-8569 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 207-212
Access rights Closed access
Type Article
Web of Science ID WOS:000074814800007

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