Lowering of plasma triiodothyronine level and sympathetic activity does not alter hypoalbuminaemia in rats fed on a diet of low protein concentration

Lowering of plasma triiodothyronine level and sympathetic activity does not alter hypoalbuminaemia in rats fed on a diet of low protein concentration

Autor Sawaya, Ana Lydia Autor UNIFESP Google Scholar
Lunn, P. G. Google Scholar
Instituição Dunn Nutr Lab
Universidade Federal de São Paulo (UNIFESP)
Resumo Previous studies have described high plasma triiodothyronine (T-3) concentrations and sympathetic activity in rats fed on low-protein diets. the present investigation examined how the nutritional status of rats fed on a low-protein diet was affected when these hormonal changes were reduced by drug administration. the low-protein diet (LP group) prevented growth, reduced plasma albumin levels, elevated plasma T-3 concentration, and increased both the weight of the interscapular brown adipose tissue (BAT) and the activity of BAT cytochrome c oxidase (EC 1.9.3.1). Lowering the plasma T-3 concentration (with carbimazole; CA group) elevated the plasma insulin concentration, promoted a small increase in the plasma albumin concentration and caused weight gain in comparison with the LP group. Reduction of sympathetic activity (with alpha-methyl-p-tyrosine; MT group) promoted a small elevation in plasma albumin concentration accompanied by a diminished Tg concentration, BAT weight, and an increase in fat deposition in relation to LP rats. in a second experiment, simultaneous lowering of the plasma T-3 concentration rind sympathetic activity (CA/MT group) resulted in weight gain associated with elevated plasma insulin concentration and fat deposition and a marked reduction in BAT cytochrome c oxidase activity. However no change in the hypoalbuminaemia was observed. the results of the present study suggest that in spite of the previously described increase in metabolic rate in rats fed on a diet with low-protein concentration when compared with controls, the mechanisms involved in the control of BAT activity and fat deposition seem to be independent of those which cause liver protein depletion and hypoalbuminaemia.
Palavra-chave hypoalbuminaemia
protein intake
triiodothyronine
Idioma Inglês
Data de publicação 1998-05-01
Publicado em British Journal of Nutrition. Wallingford: C A B International, v. 79, n. 5, p. 455-462, 1998.
ISSN 0007-1145 (Sherpa/Romeo, fator de impacto)
Publicador C A B International
Extensão 455-462
Fonte http://dx.doi.org/10.1079/BJN19980076
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000073712600009
Endereço permanente http://repositorio.unifesp.br/handle/11600/25889

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