Ca2+ release-activated channels in rat stomach smooth muscle cells

Exibir registro simples

dc.contributor.author Smaili, S. S.
dc.contributor.author Cavalcanti, P. M.
dc.contributor.author Oshiro, MEM
dc.contributor.author Ferreira, A. T.
dc.contributor.author Jurkiewicz, A.
dc.date.accessioned 2016-01-24T12:30:32Z
dc.date.available 2016-01-24T12:30:32Z
dc.date.issued 1998-01-19
dc.identifier http://dx.doi.org/10.1016/S0014-2999(97)01537-9
dc.identifier.citation European Journal of Pharmacology. Amsterdam: Elsevier B.V., v. 342, n. 1, p. 119-122, 1998.
dc.identifier.issn 0014-2999
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/25856
dc.description.abstract In rat stomach fundus, contractions induced by Ca2+ (1.8 mM) were strikingly potentiated by thapsigargin. This potentiation was partially inhibited by the blockers of Ca2+ release activated channels (CRACs), miconazole and SK&F96365 ({1-[beta-[3-(4-methoxyphenyl)propoxy]-4- methoxyphenethyl]-1H-imidazole, HCL}) and slightly blocked by the antagonist of calcium voltage-operated channels (VOCs), isradipine. in dissociated cells in a 0Ca solution, thapsigargin potentiated the increase in intracellular calcium after reintroduction of Ca2+. This potentiation was partially reduced by the CRAC blockers, but not by the VOC blockers. This data suggests that calcium influx increased due to the depletion of intracellular calcium by thapsigargin and that this influx occurs predominantly through CRACs. (C) 1998 Elsevier Science B.V. en
dc.format.extent 119-122
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof European Journal of Pharmacology
dc.rights Acesso restrito
dc.subject stomach fundus, rat en
dc.subject calcium store en
dc.subject isradipine en
dc.subject thapsigargin en
dc.subject SK & F96365 en
dc.subject miconazole en
dc.title Ca2+ release-activated channels in rat stomach smooth muscle cells en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Pharmacol, BR-04034060 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Biophys, BR-04034060 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Pharmacol, BR-04034060 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Biophys, BR-04034060 São Paulo, Brazil
dc.identifier.doi 10.1016/S0014-2999(97)01537-9
dc.description.source Web of Science
dc.identifier.wos WOS:000072455900015



Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Exibir registro simples

Buscar


Navegar

Minha conta